생후 처음으로 발생한 발열성 요로감염 환자의 배뇨성 방광 요도 조영술

Voiding cystourethrography in children with an initial episode of febrile urinary tract infection

  • 이해정 (성균관대학교 의과대학 마산삼성병원 소아과) ;
  • 이원덕 (성균관대학교 의과대학 마산삼성병원 소아과) ;
  • 김현석 (성균관대학교 의과대학 마산삼성병원 소아과) ;
  • 김태홍 (성균관대학교 의과대학 마산삼성병원 소아과) ;
  • 이주석 (성균관대학교 의과대학 마산삼성병원 소아과) ;
  • 조경래 (성균관대학교 의과대학 마산삼성병원 소아과)
  • Lee, Hae Jeong (Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Lee, Won Deok (Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Hyun Seok (Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Tae Hong (Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Lee, Joo Seok (Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Cho, Kyung Lae (Department of Pediatrics, Masan Samsung Hospital, Sungkyunkwan University School of Medicine)
  • 투고 : 2006.01.02
  • 심사 : 2006.03.27
  • 발행 : 2006.06.15

초록

목 적 : 요로감염 환자에서 VUR을 증명하기 위한 VCUG는 침습적인 검사 기법이므로 다른 비 침습적인 검사로써 VUR의 예측이 가능한지 여부를 알아보았고 이로써 VCUG를 유보할 수 있는 것인가를 연구하였다. 방 법 : 선별된 요로감염 환아에게 신 초음파, $^{99m}Tc$-DMSA 신 스캔, 그리고 VCUG를 시행하여 각각의 검사들 상호간의 관련성을 조사하였다. 결 과 : 신 초음파의 이상소견과 $^{99m}Tc$-DMSA 신 스캔에 의한 신 피질 결손과는 관련이 없었다. 신 초음파상의 이상과 VUR 사이에는 관련이 없었다. 신 초음파상의 이상소견과 VUR grade 사이에는 관련이 없었다. $^{99m}Tc$-DMSA 신 스캔에서 신 피질 결손 소견과 VUR은 상관관계가 있었으나 민감도가 낮아 $^{99m}Tc$-DMSA 신 스캔으로서 VUR을 예측하기는 어려웠다. VUR의 정도가 심할수록, 특히 grade III 이상에서 신 피질 결손이 나온 경우가 많았다. 신 초음파의 이상소견과 $^{99m}Tc$-DMSA 신 스캔에서의 신 피질 결손이 동시에 존재하는 경우는 VUR과 밀접한 상관관계가 있었고 동시에 존재하지 않은 경우 VUR이 존재하지 않을 가능성이 높았으나 민감도가 낮아 신 초음파와 $^{99m}Tc$-DMSA 신 스캔 두 검사에서 동시에 이상이 없다하더라도 VUR이 없다고 예측하기는 어려웠다. 결 론 : $^{99m}Tc$-DMSA 신 스캔에서 급성 신우신염 소견이 있는 경우 VCUG 를 적극적으로 시행해야 하고 덧붙여 신 초음파에서 수신증, 신우 요관의 확장, 신 실질 부피의 증가, 그리고 신 반향의 증감과 같은 이상 소견이 동시에 존재하는 경우 VCUG를 반드시 시행해야 하며 만일 VCUG 시행에 어려움이 있는 환아라면 신 초음파와 $^{99m}Tc$-DMSA 신 스캔에서 모두 정상인 경우 향후 면밀한 경과관찰이 이루어진다는 전제하에 VCUG 시행의 일시적 유보를 고려해야 할 것으로 사료된다.

Purpose : Because voiding cystourethrography(VCUG) is an invasive method, we studied whether VCUG could be postponed through evaluation of alternative non-invasive tests including renal ultrasonography and $^{99m}Tc$-DMSA renal scan. Methods : We reviewed the medical records of 175 patients initially diagnosed with febrile urinary tract infection during the one year period of 1999, and compared 3-tests : renal ultrasongraphy, $^{99m}Tc$-DMSA renal scan, and VCUG. Results : Renal ultrasonography didn't contribute to the prognostication of pyelonephritis(photopenic areas) or vesicoureteral reflux(VUR). Presentation of photopenic areas in $^{99m}Tc$-DMSA renal scan was related to VUR. If both findings of renal ultrasonography and $^{99m}Tc$-DMSA renal scans were normal, this condition was closely related to normal results in VCUG. And if both examinations were abnormal, the condition was closely related to VUR. But this state could not always guarantee the normal result from VCUG because of low sensitivity in finding VUR. Conclusion : In cases in which acute phyelonephritis is demonstrated by $^{99m}Tc$-DMSA renal scan, VCUG is required. In addition to this, if the conditions of hydronephrosis, vesicoureteral dilatation, increases of renal volume, and changes of echogenesity are shown by renal ultrasonography, VCUG should be performed. If a patient has difficulty undergoing VCUG, temporary postponement of VCUG can be taken into consideration, but only in cases where both examinations of renal ultrasonography and $^{99m}Tc$-DMSA renal scan are normal. Nevertheless, close observation is be advised even in this case.

키워드

참고문헌

  1. Woolf AS, Wilcox DT. Understanding primary vesicoureteric reflux and associated nephropathies. Curr Pediatr 2004;14:563-7 https://doi.org/10.1016/j.cupe.2004.07.012
  2. Merrick MV, Notghi A, Chalmers N, Wilkinson AG, Uttley WS. Longterm follow up to determine the prognostic value of imaging after urinary tract infections. Part 2 : Scarring. Arch Dis Child 1995;72:393-6 https://doi.org/10.1136/adc.72.5.393
  3. Jung SW, Jung KH, Kim MH, Lee JE, Hong YJ, Son BK. Factors associated with renal scarring in children with a first episode of febrile urinary tract infection. J Korean Soc Pediatr Nephro 2005;9:56-63
  4. You SH, Hong JS, Lee DH. Is evaluation with voiding cystourethrography necessary for children with a febrile urinary tract infection- Korean J Urol 2004;45:219-23
  5. Sargent M. What is the normal prevalence of vesicoureteric reflux? Pediatr Radiol 2000;30:587-93 https://doi.org/10.1007/s002470000263
  6. Phillips DA, Watson AR, MacKinlay D. Distress and the micturation cystourethrogram : does preparation help? Acta Paediatrica 1998;87:175-9 https://doi.org/10.1080/08035259850157624
  7. International Reflux Study Committee. Medical versus surgical treatment of primary vesicoureteral reflux : report of the International Reflux Study Committee. Pediatrics 1981; 67:392-400
  8. Goonasekera CD, Shah V, Wade AM, Barratt TM, Dillon MJ. 15-year follow-up of renin and blood pressure in reflux nephropathy. Lancet 1996;347:640-3 https://doi.org/10.1016/S0140-6736(96)91201-5
  9. McGladdery SJ, Aparicio S, Verrier-Jones K, Roberts R, Sacks SH. Outcome of pregnancy in an Oxford-Cardiff cohort of women with previous bacteriuria. Q J Med 1992;83: 533-9
  10. Smellie J, Barratt TM, Chantler C, Gordon I, Prescod NP, Woolf AS, et al. Medical versus surgical treatment in children with severe bilateral vesicoureteric reflux and bilateral nephropathy : a randomised trial. Lancet 2001;357:1329-33 https://doi.org/10.1016/S0140-6736(00)04520-7
  11. Bailey RR, Lynn KL, Smith AH. Long-term followup of infants with gross vesicoureteral reflux. J Urol 1992;148: 1709-11 https://doi.org/10.1016/S0022-5347(17)37010-6
  12. Gordon I, Barkovics M, Pindoria S, Cole TJ, Soolf AS. Primary vesicoureteric reflux as a predictor of renal damage in children hospitalized with urinary tract infection : a systematic review and meta-analysis. J Am Soc Nephrol 2003; 14:739-44 https://doi.org/10.1097/01.ASN.0000053416.93518.63
  13. Zamir G, Sakran W, Horowitz Y, Koren A, Miron D. Urinary tract infection : is there a need for routine renal ultrasonography? Arch Dis Child 2004;89:466-8 https://doi.org/10.1136/adc.2002.019182
  14. Alejandro H, Martin C, Robert WH, Marc B, Diana HK, Ellen RW. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 2003;16:195-202
  15. Kass EJ, Fink-Bennett D, Cacciarelli AA, Balon H, Pavlock S. The sensitivity of renal scintigraphy and sonography in detecting nonobstructive acute pyelonephritis. J Urol 1992; 148:606-8 https://doi.org/10.1016/S0022-5347(17)36667-3
  16. Eun BY, Chung YM, Kang HG, Ha IS, Cheong HI, Choi Y, et al. Urinary track infections in febrile infants under three months of age. J Korean Pediatr Soc 2003;46:265-70
  17. Foresman WH, Hulbert WC Jr, Rabinowitz R. Does urinary tract ultrasonography at hospitalization for acute pyelonephritis predict vesicoureteral reflux? J Urol 2001;165: 2232-4 https://doi.org/10.1016/S0022-5347(05)66172-1
  18. Michael G, Tzvy B, Tifha H, Ietay Z, Mordechay A. The etiology of renal scars in infants with pyelonephritis and vesicoureteral reflux. Pediatr Nephrol 2000;14:385-8 https://doi.org/10.1007/s004670050779
  19. Cesare P, Pier FR, Luigi M, Rosario DT, Angela LM. Unilateral vesicoureteric reflux : Low prevalence of contralateral renal damage. J Pediatr 2001;138:875-9 https://doi.org/10.1067/mpd.2001.114336
  20. Rosenberg AR, Rossleigh MA, Brydon MP, Bass SJ, Leighton DM, Farnsworth RH. Evaluation of acute urinary infection in children by dimercaptosuccinic acid scintigraphy; a prospective study. J Urol 1992;148:1746-9 https://doi.org/10.1016/S0022-5347(17)37019-2