Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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The Neuroprotective and Neurotrophic Effects of Korean Gardenia (Gardenia jasminoides Ellis) in PC12h Cells

  • Park, Kum-Ju (Institute of Food and Culture R&D Center, Pulmuone Co., Ltd.) ;
  • Ha, Hyo-Cheol (Institute of Food and Culture R&D Center, Pulmuone Co., Ltd.) ;
  • Kim, Hyun-Su (Department of Microbial Engineering, Kunkuk University) ;
  • Chiba, Kenzo (Department of Biodynamics, Faculty of Pharmaceutical Sciences, Hokuriku University) ;
  • Yeo, Ik-Hyun (Institute of Food and Culture R&D Center, Pulmuone Co., Ltd.) ;
  • Lee, Sang-Yun (Institute of Food and Culture R&D Center, Pulmuone Co., Ltd.)
  • Published : 2006.10.30
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Abstract

We examined the neuroprotective and neurotrophic effects of genipin fractionated from gardenia (Gardenia jasminoides Ellis) originating from Korea. The neurotrophic effects of the genipin containing fraction was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells. The genipin containing fraction from Korean gardenia promoted neurite outgrowth in PC12h cells in this study, similar to previously reported effects by Wako Chemical, Japan. When cells were treated with the genipin containing fraction prior to ${\beta}$-amyloid peptide treatment (active domain of A peptide 25-35 treated), toxicity was significantly diminished (p<0.0l). These results suggest that genipin prepared from Korean gardenia might potentially be used as a precautionary agent in neurodegenerative disease, such as Alzheimer's disease, etc.

Keywords

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