Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Water Extracts of Cultured Mountain Ginseng Stimulate Immune Cells and Inhibit Cancer Cell Proliferation

  • Oh, Chan-Ho (Department of Biotechnology, Woosuk University) ;
  • Kang, Pil-Sung (Department of Biotechnology, Woosuk University) ;
  • Kim, Jae-Whune (Microplants Co., Ltd.) ;
  • Kwon, Jin (Department of Prosthetics & Orthotics, Korea National College of Rehabilitation & Welfare) ;
  • Oh, Suk-Heung (Department of Biotechnology, Woosuk University)
  • Published : 2006.06.30
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Abstract

Water extracts obtained from cultured mountain ginseng (CMG) were evaluated for their ability to stimulate immune cells and inhibit cancer cell proliferation. The lymphocyte subpopulation in mouse splenocytes in vivo was significantly increased by the administration of the CMG extract (27.4 mg/mouse). Interleukin-2 and ${\gamma}$-interferon in the mice serum increased up to 30% in CMG extract-treated mice. At a concentration of 1.37 mg/mL, nitric oxide increased up to 400% in the macrophage cell line treated with CMG extract. The CMG extract significantly retarded the proliferation of human acute promyelocytic (HL60), human histiocytic (U937), and mouse lymphocytic (L1210) leukemia cell lines in vitro at concentrations over 2.74-13.7 mg/mL. In addition, CMG extract treatments (1.37 mg/mL and 2.74 mg/mL) lead to the increased expression of the p53 gene and protein in cultured U937 leukemia cell lines. These results indicate that water extracts of CMG are capable of both immune cell stimulation and cancer cell growth inhibition.

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References

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