Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Enhancement of Immunological Activities in Mice by Oral Administration of Pectic Polysaccharides from Eleutherococcus senticosus

  • Sung, Ji-Yun (Food Business R&D, Boryung Co., Ltd.) ;
  • Yoon, Taek-Joon (Department of Biotechnology, College of Biomedical and Health Science, Konkuk University and Bio-Food and Drug Research Center) ;
  • Yu, Kwang-Won (Department of Kimchi and Food Science, Chungju National College of Science and Technology) ;
  • Lee, Kwang-Ho (Department of Biotechnology, College of Biomedical and Health Science, Konkuk University and Bio-Food and Drug Research Center) ;
  • Lee, Ho (Department of Food Science and Biotechnology, Kyonggi University)
  • Published : 2006.02.28
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Abstract

Ability of pectic polysaccharides isolated from Eleutherococcus senticosus EN-3 to inhibit tumor metastasis and induce antigen-specific immune response after oral administration in mice was assessed. Consecutive oral administration of EN-3 before tumor inoculation dramatically inhibited tumor metastasis produced by colon26-M3.1 and B16-BL6 cells. When Peyer's patch cells isolated from mouse intestine were co-cultured with EN-3, proliferation of Peyer's patch cells was induced. Mice co-administered with EN-3 and ovalbumin (OVA) showed significantly higher production of OVA-specific IgA in intestinal washing as well as IgG in serum than those administered with OVA alone. Payer's patch cells of mice immunized with OVA plus EN-3 showed much higher proliferating activity than those of mice immunized with OVA alone. Proliferating activity increased dose-dependently, indicating EN-3 specifically enhanced mucosal immune response to OVA. These results suggested EN-3 could significantly stimulate Peyer's patch cells either non-specifically or antigen-specifically, possibly playing important role in enhancement of mucosal and systemic immune systems.

Keywords

References

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