자발성 종격동기종의 임상적 고찰

Clinical Analysis of Spontaneous Pneumomediastinum

  • 전순호 (한양대학교 구리병원 흉부외과학교실) ;
  • 위장섭 (한양대학교 흉부외과학교실) ;
  • 이철범 (한양대학교 구리병원 흉부외과학교실) ;
  • 김혁 (한양대학교 흉부외과학교실) ;
  • 김영학 (한양대학교 흉부외과학교실)
  • Chon Soon-Ho (Department of Thoracic and Cardiovascular Surgery, Hanyang University Guri Hospital) ;
  • Wee Jang Seop (Department of Thoracic and Cardiovascular Surgery, Hanyang University Hospital) ;
  • Lee Chul Burm (Department of Thoracic and Cardiovascular Surgery, Hanyang University Guri Hospital) ;
  • Kim Hyuck (Department of Thoracic and Cardiovascular Surgery, Hanyang University Hospital) ;
  • Kim YoungHak (Department of Thoracic and Cardiovascular Surgery, Hanyang University Hospital)
  • Published : 2006.01.01

Abstract

배경: 자발성 종격동기종(SPM)은 상대적으로 드문 양성 질환으로 어떤 유발인자나 질병 없이 젊은 성인에게서 일반적으로 나타난다. 본 연구의 목적은 더 불편한 진단절차의 필요여부를 판단하고 자발성 기종격의 진단과 치료의 기준을 확립하는데 있다. [대상 및 방법: 1997년 1월부터 2004년 6월까지 한양대학교 서울병원과 구리병원에서 18명의 환자를 대상으로 회고적인 연구를 시행했다 모든 환자들은 기흉이나 외상 또는 압력손상의 증거가 없이 종격동에 공기가 있었다. 결과: 18명의 환자들 중에서 2명의 여자 환자를 제외한 대부분은 남자 환자였다. 환자들의 평균 연령은 20.95세였으며, 표준편차는 14.3세였다. 가장 흔한 증상은 흉통, 호흡곤란, 기침이었다. 검사로는 모든 환자에게서 단순흉부 촬영이 행해졌으며, 10명에게는 흉부 단층 촬영이, 6명에게는 기관지내시경이, 3명에게는 식도 조영술이 행해졌다. 평균 재원기간은 10.9일이었다. 모든 환자들은 보전적인 방법으로 치유되었으며, 1$\∼$8년간의 추적관찰 도중 단 한차례만 재발하였다. 결론: 자발성 종격동기종(SPM)은 폐간질에서 폐포의 파열에 의해 발생하는 것으로, 폐문이나 종격동으로 공기의 박리를 유발한다. 비록 자발성 종격 동기종(SPM)이 자기 제한적인 질병이지만 다른 이차적인 질병을 감별하기 위해 단순 흥부촬영과 흉부 단층촬영을 포함한 검사는 반드시 행해져야 한다. 보다 적극적인 검사는 필요하지 않을 것으로 생각된다.

Background: Spontaneous pneumomediastinum (SPM) is a relatively rare and benign condition that generally occurs in young adults without any precipitating factor or disease. The purpose of this study was to assess whether more uncomforting diagnostic procedures are necessary and to establish standards in the diagnosis and treatment of spontaneous pneumomediastinum. Material and Method: A retrospective study was done on 18 patients from the hospitals of Hanyang University Seoul Hospital and Hanyang University Guri Hospital between February, 1997 and June, 2004. All patients had presence of mediastinal air without a pneumothorax and no evidence of trauma or barotrauma. Result: Among the 18 patients, the majority were male patients with only two female patients. Their mean age was 20.95 years old with standard deviation of 14.3 years. The most common complaints were chest pain, dyspnea, and coughing. Evaluation included simple chest roentgenogram in all patients, 10 patients had a chest tomographic scan, 10 patients had an esophagoscopic exam, 6 patients had a bronchofiberoscopic exam, and 3 patients had an esophagogram done. The mean hospital stay was 10.9 days. All patients were treated conservatively and in a follow-up of 1 $\∼$ 8 years only one recurrence was found. Conclusion: SPM is caused by alveolar rupture in the pulmonary interstitium leading to dissection of air towards the hilum and mediastinum. Although SPM is a self-limiting condition, evaluation should include chest roentgenogram and chest tomographic scans to rule out any other secondary condition. More aggressive evaluation seems unnecessary.

Keywords

References

  1. Hamman L. Spontaneous mediastinal emphysema. Bull Johns Hopkins Hosp. 1939;64:1-21
  2. Yellin A. Gapany-Gapanavicius M, Lieberman Y. Spontaneous pneumomediastinum: is it a rare cause of chest pain? Thorax 1983;38:383-5 https://doi.org/10.1136/thx.38.5.383
  3. Munsell WP. Pneumomediastinum: a report of 28 cases and review of the literature. JAMA 1967;202:689-93 https://doi.org/10.1001/jama.202.8.689
  4. Chalumeau M, Le Clainche L, Sayeg N, et al. Spontaneous pneumomediastinum in children. Pediatric Pulmonology 2001; 31:67-75 https://doi.org/10.1002/1099-0496(200101)31:1<67::AID-PPUL1009>3.0.CO;2-J
  5. Abolnik I, Lossos IS, Breuer R. Spontaneous pneumomediastinum. A report of 25 cases. Chest 1991;100:93-5 https://doi.org/10.1378/chest.100.1.93
  6. Laennec RTH. A treatise on diseases of the chest and on mediate auscultation. 3rd ed. London: Thomas & George Underwood 1829;152-78
  7. Macklin MT, Macklin CC. Malignant interstitial emphysema of the lungs and mediastinum as an important occult complication in many respiratory diseases and other conditions: interpretation of clinical literature in light of laboratory experiment. Medicine 1844;23:281-358
  8. Jamadar DA, Kazerooni EA, Hirschl RB. Pneummediastinum: Elucidation of the anatomic pathway by liquid ventilation. J Comp Assist Tomog 1996;20:309-11 https://doi.org/10.1097/00004728-199603000-00027
  9. Weissberg D, Weissberg D. Spontaneous mediastinal emphysema. Eur J Cardiothorac Surg 2004;26:885-8 https://doi.org/10.1016/j.ejcts.2004.05.050
  10. Chapdelaine J, Beaunoyer M, Daigneault P, et al. Spontaneous pneumomediastinum: Are we overinvestigating? J Ped Surg 2004;39:681-4 https://doi.org/10.1016/j.jpedsurg.2004.01.045
  11. Panacek EA, Singer AJ, Sherman BW, Prescott A, Rutherford WF. Spontaneous pneumomediastinum: clinical and natural history. Ann Emerg Med 1992;21:67-72 https://doi.org/10.1016/S0196-0644(05)82241-3
  12. Weathers LS, Brooks WG, DeClue TJ. Spontaneous pneumomediastinum in a patient with ketoacidosis: a potentially hidden complication. South Med J 1995;88:483-5 https://doi.org/10.1097/00007611-199504000-00022
  13. Kim KI, Lee JW, Lee CH, Park SK. Polypoid endobronchial Hodgkin's isease with pneumomediastinum. Br J Radiol 1999;72:392-4 https://doi.org/10.1259/bjr.72.856.10474502
  14. Sikdar T, Macvivar D, Husband JE. Pneumomediastinum complicating bleomycin related lung damage. Br J Radiol 1998; 71:1202-4 https://doi.org/10.1259/bjr.71.851.10434917
  15. Koullias GJ, Korkolis DP, Wang XJ, Hammond GL. Current assessment and management of spontaneous pneumomediastinum: experience in 24 adult patients. Eur J Cardiothorac Surg 2004;25:852-5 https://doi.org/10.1016/j.ejcts.2004.01.042
  16. Gerazounis M, Athanassiadi K, Kalantzi N, Moustardas M. Spontaneous pneumomediastinum: A rare benign entitiy. J Thorac Cardiovasc Surg 2003;126:188-91
  17. Jougan JB, Ballester M, Delcambre F, MacBride T, Drower CE, Velly JF. Assessment of spontaneous pneumomediastinum: experience with 12 patients. Ann Thorac Surg 2003;75: 1711-4 https://doi.org/10.1016/S0003-4975(03)00027-4
  18. Hoover LR, Febinger DL, Tripp HF. Rhinolalia: an underappreciated sign of pneumomediastinum. Ann Thorac Surg 2000;69:615-6 https://doi.org/10.1016/S0003-4975(99)01114-5
  19. Kaneki T, Kubo K, Kawashima A, Koizumi T, Sekiguchi M, Sone S. Spontaneous pneumomediastinum in 33 patients: Yield of chest computed tomography for the diagnosis of the mild type. Respiration 2000;67:408-11 https://doi.org/10.1159/000029539
  20. Cyrlak D, Milne E. Pneumomediastinum: A diagnostic problem. CRC Crit Rev Diagn Imaging 1984;23:75-117
  21. Langwieler TE, Steffani KD, Bogoevski DP, Mann O, Izbicki JR. Spontaneous pneumomediastinum. Ann Thorac Surg 2004;78:711-3 https://doi.org/10.1016/j.athoracsur.2003.09.021
  22. Halperin AK, Deichmann RE. Spontaneous pneumomediastinum: A report of 10 cases and review of the literature. N C Med J 1985;46:21-3
  23. Channer KS, Roberts JC, Jeyasingham K. Recurrent idiopathic pneumomediastinum. Postgrad Med J 1985;61:1073-5 https://doi.org/10.1136/pgmj.61.722.1073
  24. Lee SK, Im JS, Cho NS. Clinical evaluation of pneumomediastinum in adult. Korean J Thorac Cardiovasc Surg 1999; 32:43-8