Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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The Relationship Between Interleukin $1{\beta}$ Gene Polymorphism and Renal Involvement in Henoch-$Sch\ddot{o}nlein$ Purpura

Henoch-$Sch\ddot{o}nlein$ Purpura에서 Interleukin $1{\beta}$ 유전자 다형성과 신장 침범과의 연관성

  • Na, Hyoung-Joon (Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine) ;
  • Go, Il-Yong (Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine) ;
  • Yoon, Joon-Ho (Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine) ;
  • Yeh, Byung-Il (Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine) ;
  • Kim, Hwang-Min (Department of Pediatrics and Biochemistry Yonsei University Wonju College of Medicine)
  • 나형준 (연세대학교 원주의과대학 소아과학교실, 생화학교실) ;
  • 고일용 (연세대학교 원주의과대학 소아과학교실, 생화학교실) ;
  • 윤준호 (연세대학교 원주의과대학 소아과학교실, 생화학교실) ;
  • 예병일 (연세대학교 원주의과대학 소아과학교실, 생화학교실) ;
  • 김황민 (연세대학교 원주의과대학 소아과학교실, 생화학교실)
  • Published : 2006.10.31
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Abstract

Purpose : High interleukin-1 beta(IL-$1{\beta}$) expression in the skin biopsy specimens of patients with Henoch-$Sch\ddot{o}nlein$ Purpura(HSP) has been observed. We examined IL-$1{\beta}$ gene polymorphism in patients with HSP. The purpose of this study is to examine the relationship between IL-$1{\beta}$ gene polymorphism and renal involvement in HSP. Methods : Patients from mideast Korea with HSP were studied. All patients had at least 6 months of follow up. Patients and ethnically matched controls were genotyped for IL-$1{\beta}$ gene polymorphism by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Results : Thirty-four patients(all younger than 15 years old) who had been diagnosed with HSP and 27 controls were examined. No allele or genotype differences between the HSP and control groups were observed. No significant association between the carriage of IL-$1{\beta}$(-511) T allele and renal involvement(P=0.525, OR:1.417, CI:0.545-3.686) was found. Conclusion : In unselected patients with HSP, carriage of IL-$1{\beta}$(-511) T allele does not appear to influence renal involvement.

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