Journal of The Korean Dental Society of Anesthesiology (대한치과마취과학회지)

The Korean Dental Society of Anesthsiology (대한치과마취과학회)
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Effect of Submucosal Midazolam on Percutaneous Saturation Percentage of Oxygen ($SpO_2$), End-tidal Carbon Dioxide ($EtCO_2$) and Physiologic Response When Combined with Chloral Hydrate, Hydroxyzine and Nitrous Oxide Sedation

구강 점막 하 주입 Midazolam과 경구 투여한 Chloral Hydrate의 용량에 따른 산소 포화도 및 생징후 변화에 대한 비교 연구

  • Yu, Ji-Hye (Department of Pediatric Dentistry, Ewha Womans University Graduate School of Clinical Dentistry) ;
  • Kim, Yun-Hee (Department of Pediatric Dentistry, Ewha Womans University Graduate School of Clinical Dentistry) ;
  • Jung, Sang-Hyuk (Department of Preventive Medicine, College of Medicine, Ewha Womans University) ;
  • Baek, Kwang-Woo (Department of Pediatric Dentistry, Ewha Womans University Graduate School of Clinical Dentistry)
  • 유지혜 (이화여자대학교 임상치의학대학원 소아치과학교실) ;
  • 김윤희 (이화여자대학교 임상치의학대학원 소아치과학교실) ;
  • 정상혁 (이화여자대학교 의과대학 예방의학교실) ;
  • 백광우 (이화여자대학교 임상치의학대학원 소아치과학교실)
  • Published : 2006.12.30
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Abstract

Background: The aim of this study was to examine the difference of $SpO_2$, PR, $EtCO_2$, RR with submucosal injection of midazolam to oral chloral hydrate and hydroxyzine for pediatric patients Methods: Thirty two sedation cases were performed in this study. Patients were randomly classified into one group taking oral CH (60 mg/kg). hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.1 mg/kg) and the other group recieving oral CH (50 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.2 mg/kg). For evaluating the depth of sedation. data including saturation percentage of oxygen ($SpO_2$), pulse rate (PR), end-tidal carbon dioxide ($EtCO_2$), respiratory rate (RR) and the behavior scale were checked every 2 minutes and were collected for only 40 minutes from the beginning of treatment and were analyzed using Two independent sample T-test. Results: Analysis showed no significant difference in the mean $SpO_2$, PR, $EtCO_2$, RR during sedation between two groups (P > 0.05). The values of $SpO_2$, PR, $EtCO_2$ and RR for both groups remained within the normal values. Conclusions: The results of this present study indicate that combination of oral CH, hydroxyzine, nitrous oxide gas inhalation and submucosal injection of midazolam improved the sedation quality without compromising safety.

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