Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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[ $\alpha$ ]-Glucosidase Inhibitors from the Roots of Codonopsis lanceolata Trautv

  • Jung, Suk-Whan (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University) ;
  • Han, Ae-Jin (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University) ;
  • Hong, Hae-Jin (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University) ;
  • Choung, Myoung-Gun (Department of Pharmacognosy Material Development, Kangwon National University) ;
  • Kim, Kwan-Su (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University) ;
  • Park, Si-Hyung (Department of Medicinal Plant Resources, Division of Applied BioScience, Mokpo National University)
  • Published : 2006.12.31
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Abstract

The roots of Codonopsis lanceolata afforded tangshenoside I(1) and $\beta$-adenosine (2) as $\alpha$-glucosidase inhibitors. Their structures were unambiguously determined by 1D and 2D NMR data including HMQC and HMBC experiments. Compounds 1 and 2 exhibited weak $\alpha$-glucosidase inhibitory activities in vitro with $IC_{50}$ of 1.4 and 9.3 mM, respectively.

Keywords

References

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