Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effects of Ginseng Radix herbal acupuncture on TNBS-induced colitis in rats

TNBS 유발 대장염(大腸炎)에 의한 체중 및 혈액상 변화에 대한 인삼(人蔘) 약침(藥鍼)의 효과

  • Kim Jong-Sung (Dept. of Meridian & Acupoint, college of Oriental Medicine, Wonkwang University) ;
  • Chun Sang-Woo (Dept. of Physiology, College of Dentistry, Wonkwang University) ;
  • Park Sang-Yeon (Dept. of Meridian & Acupoint, college of Oriental Medicine, Wonkwang University) ;
  • Park Sung-Ik (Dept. of Meridian & Acupoint, college of Oriental Medicine, Wonkwang University) ;
  • Kim Kyung-Sik (Dept. of Meridian & Acupoint, college of Oriental Medicine, Wonkwang University) ;
  • Kim Jae-Hyo (Dept. of Meridian & Acupoint, college of Oriental Medicine, Wonkwang University) ;
  • Koo Sung-Tae (Dept. of Medical Research, Korea Institute of Oriental Medicine) ;
  • Sohn In-Chul (Dept. of Meridian & Acupoint, college of Oriental Medicine, Wonkwang University)
  • 김종성 (원광대학교 한의과대학 경혈학교실) ;
  • 천상우 (원광대학교 한의과대학 치과대학 치의학과) ;
  • 박상연 (원광대학교 한의과대학 경혈학교실) ;
  • 박성익 (원광대학교 한의과대학 경혈학교실) ;
  • 김경식 (원광대학교 한의과대학 경혈학교실) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실) ;
  • 구성태 (한국한의학연구원 의료연구부) ;
  • 손인철 (원광대학교 한의과대학 경혈학교실)
  • Published : 2006.12.27
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Abstract

Objectives : The purpose of the present study is to evaluate the effects of herbal acupuncture with Ginseng Radix for the treatment to intestinal disease in the rat with 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) induced colitis. Methods : All animals were subjected to the injection of saline $(300{\mu}{\ell},\;500{\mu}{\ell})$ for a study control or TNBS $(300{\mu}{\ell},\;500{\mu}{\ell})$ into the lumen of the colon, 8cm proximal to the anus through the intestine. Ginseng Radix herbal acupuncture ($20mg/m{\ell},\;0.4m{\ell}$) were injected to the both $Hapgok(LI_4)$ acupoints at 2nd injection of TNBS in rats. Thus, the body weight, RBC count, WBC count, total protein, IgG levels and IgM levels were observed to study the effects of Ginseng Radix herbal acupuncture. Results : Ginseng Radix herbal acupuncture on $Hapgok(LI_4)$ for TNBS-induced colitis inhibited the body weight loss rate but did not affect RBC and WBC counts. Furthermore, it inhibited the reduction of total protein concentration and serum IgG and IgM levels in TNBS induced colitis were recovered. Conclusions : Herbal acupuncture with Ginseng Radix helps recover the TNBS-induced colonic damage and may be an important method for treatment of the colitis.

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