Intramedullary Subependymoma of the Thoracic Spinal Cord

  • Jang, Woo-Youl (Department of Neurosurgery, Chonnam National University, Medical School) ;
  • Lee, Jung-Kil (Department of Neurosurgery, Chonnam National University, Medical School) ;
  • Kim, Jae-Hyoo (Department of Neurosurgery, Chonnam National University, Medical School) ;
  • Kim, Soo-Han (Department of Neurosurgery, Chonnam National University, Medical School)
  • Published : 2006.05.30

Abstract

An Intramedullary subependymoma of the spinal cord is a rare tumor with only 43 reported cases in the literature. Most of them are reported to be localized within the cervical spinal cord. We report a rare case of a thoracic spine intramedullary subependymoma in a 37-year-old female who presented with back pain and radiating leg pain. Subtotal resection and post-operative radiotherapy were performed. Subependymomas developing in the spinal cord are benign with a low proliferative potential. Complete resection of the tumor appears to be the optimal method for a complete cure. However aggressive surgery may cause severe neurological deficit. Therefore, if severe neurological deficits are expected after complete removal, a partial removal and postoperative radiation therapy is an alternative method for treatment in selected cases. A large-scale randomized study is mandatory to clarify the effectiveness of radiotherapy and to establish the recurrence rate and prognosis with respect to the surgical removal of these tumors.

Keywords

References

  1. Bardella L, Artico M, Nucci F : Intramedullary subependymoma of the cervical spinal cord. Surg Neurol 29 : 326-329, 1988 https://doi.org/10.1016/0090-3019(88)90167-X
  2. Casey AT, Marsh H, Wilkins P : Subependymoma of thoracic cord : potential pitfalls in diagnosis. Br J Neurosurg 7 : 319-322, 1993 https://doi.org/10.3109/02688699309023818
  3. Dario A, Fachinetti P, Cerati M, Dorizzi A : Subependymoma of the spinal cord : case report and review of the literature. J Clin Neurosci 8 : 48-50, 2001 https://doi.org/10.1054/jocn.2000.0794
  4. Herrmann HD, Neuss M, Winkler D : Intramedullary spinal cord tumors resected with CO2 laser microsurgical technique : recent experience in fifteen patients. Neurosurgery 22 : 518-522, 1988 https://doi.org/10.1227/00006123-198803000-00011
  5. Jallo GL, Zagzag D, Epstein F : Intramedullary subependymoma of the spinal cord. Neurosurgery 38 : 251-257, 1996 https://doi.org/10.1097/00006123-199602000-00004
  6. Jo KW, Jung JH, Jeun SS, Kim MC : Cervical subependymoma presenting as an extramedullary tumor. J Korean Neurosurg Soc 37 : 150-153, 2005
  7. Kremer P, Zoubaa S, Schramm P : Intramedullary subependymoma of the lower spinal cord. Br J Neurosurg 18 : 548-551, 2004 https://doi.org/10.1080/02688690400012608
  8. Lombardi D, Scheithauer BW, Mayer FB, Forbes GS, Shaw EG, Gibney DJ, et al : Symptomatic subependymoma : a clinicopathological and flow cytometric study. J Neurosurg 75 : 583-588, 1991 https://doi.org/10.3171/jns.1991.75.4.0583
  9. Mstsumoto K, Nakagaki H : Intramedullary subependymoma occupying the right half of the thoracic spinal cord : case report. Neurol Med Chir (Tokyo) 42 : 349-353, 2002 https://doi.org/10.2176/nmc.42.349
  10. Pagni CA, Canavero S, Giordana MT, Mascalchi M, Arnetoli G : Spinal intramedullary subependymomas : case report and review of the literature. Neurosurgery 30 : 115-117, 1992 https://doi.org/10.1227/00006123-199201000-00021
  11. Salcman M, Mayer R : Intramedullary subependymoma of the cervical spinal cord : case report. Neurosurgery 14 : 608-611, 1984 https://doi.org/10.1227/00006123-198405000-00019
  12. Sarkar C, Mukhopadhyay S, Ralte AM, Sharma MC, Gupta A, Gaikwad S, et al : Intramedullary subependymoma of the spinal cord : a case report and review of literature. Clin Neurol Neurosurg 106 : 63-68, 2003
  13. Shimada S, Ishizawa K, Horiguchi H, Shimada T, Hirose T : Subependymoma of the spinal cord and review of the literature. Pathology international 53 : 169-173, 2003 https://doi.org/10.1046/j.1440-1827.2003.01450.x
  14. Vaquero J, Martinez R, Vegazo I, Ponton P : Subependymoma of the cervical spinal cord. Neurosurgery 24 : 625-627, 1989 https://doi.org/10.1227/00006123-198904000-00024