Journal of Korean Neurosurgical Society

  • 제39권2호
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  • Pages.148-151
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  • 2006
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  • 2005-3711(pISSN)
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  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
권호 표지

Brain Metastasis from Dermatofibrosarcoma Protuberans

  • Kim, Wook-Ha (Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute) ;
  • Park, Chul-Kee (Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute) ;
  • Kim, Dong-Gyu (Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute) ;
  • Jung, Hee-Won (Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute)
  • 발행 : 2006.02.28
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초록

Dermatofibrosarcoma protuberans[DFSP] is an uncommon fibrohistiocytic tumor characterized by aggressive local invasion and consequent local recurrence rather than distant metastasis. We present a case of a 51-year-old male patient with a typical cutaneous DFSP, which showed local recurrences and distant metastasis to the central nervous system[CNS] and the lung after 15 years from the initial diagnosis. CNS metastatic lesions recurred in 5 months after surgical resection of the first CNS lesion. These metastatic tumors were treated by open surgery and gamma-knife radiosurgery. Despite continuous medication of oral chemotherapeutic agent, the patient died during 1-year follow-up period.

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참고문헌

  1. Auer IA, Auer RN : Metastatic dermatofibrosarcoma protuberans mimicking meningioma. Clin Neuropathol 17 : 190-193, 1998
  2. Enziger FM, Weiss SW : Soft Tissue Tumors, ed 3. Saint Louis : Mosby, 1995, pp491-506
  3. Jo TY, Kim SD, Kim SH, Park JY : A case of recurrent dermatofibrosarcoma of the scalp. J Korean Neurosurg Soc 37 : 241-243, 2005
  4. Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR : Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer 100 : 623-626, 2002 https://doi.org/10.1002/ijc.10535
  5. McPeak CJ, Cruz T, Nicastri AD : Dermatofibrosarcoma protuberans : an analysis of 86 cases : five with metastases. Ann Surg 166 : 803-815, 1967 https://doi.org/10.1097/00000658-196711000-00011
  6. Rutgers EJ, Kroon BB, Albus-Lutter CE, Gortzak E : Dermatofibrosarcoma protuberans : treatment and prognosis. Eur J Surg Pathol 16 : 921-925, 1992 https://doi.org/10.1097/00000478-199210000-00001
  7. Sasaki M, Ishida T, Horiuchi H, MacHinami R : Dermatofibrosarcoma protuberans : an analysis of proliferative activity, DNA flow cytometry and p53 overexpression with emphasis on its progression. Pathol Int 49 : 799-806, 1999 https://doi.org/10.1046/j.1440-1827.1999.00944.x
  8. Sirvent N, Maire G, Pedeutour F : Genetics of dermatofibrosarcoma protuberans family of tumors : from ring chromosome to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer 37 : 1-19, 2003 https://doi.org/10.1002/gcc.10202
  9. Skidmore RA Jr, Flowers FP : Nonmelanoma skin cancer. Med Clin North 82 A : 1309-1323, 1998
  10. Suit H, Spiro I, Mankin HJ, Efird J, Rosenberg AE : Radiation in management of patients with dermatofibrosarcoma protuberans. J Clin Oncol 14 : 2365-2369, 1996 https://doi.org/10.1200/JCO.1996.14.8.2365
  11. Uematsu Y, Fukai J, Tamura M, Owai Y, Obayashi S, Nakai K, et al : Distant metastasis of dermatofibrosarcoma protuberans of the scalp : case report. Neurol Med Chir (Tokyo) 43 : 493-496, 2003 https://doi.org/10.2176/nmc.43.493