Management of Recurrent Vestibular Schwannomas

  • Kim, Wook-Ha (Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute) ;
  • Park, Chul-Kee (Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute) ;
  • Kim, Dong-Gyu (Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute) ;
  • Jung, Hee-Won (Department of Neurosurgery, Seoul National University College of Medicine, Clinical Research Institute)
  • Published : 2006.02.28

Abstract

Objective : Management of recurrent vestibular schwannomas[VS] after microsurgery or radiosurgery is a complicated subject. However, few studies have documented the outcome of recurrent VS. The authorsreviewclinicalexperience of recurrent VS management and analyzed the efficacy of treatment modalities. Methods : Between 1990 and 2002, 293 patients harboring unilateral VS underwent, microsurgery, radiosurgery, microsurgery followed by radiosurgery. Of these, 26 procedures [in 20 patients] were performed to assessed from an increased tumor size by magnetic resonance imaging[MRI]. The mean age of patients with recurred VS was 46.9 years and the mean follow-up period was 68 months. Radiological characteristics were investigated and growth rates of recurred tumors were calculated by measuring changes in tumor diameter on MRI after treatment. Results : MRI characteristics revealed a lobulated contour in 75% and a cyst in 60% of the patients. Only 1 patient showed neither lobulation nor a cyst. The average diameter of the recurrent tumors were 36.9mm. The overall tumor control rate for initial management was 87.4%, 94.7%, and 98.5% for microsurgery, radiosurgery, and microsurgery plus radiosurgery, respectively. However, control rates for recurrent tumors were lower at 85%, 63%, and 80%, respectively. Conclusion : A cystic nature and a lobulated tumor contour are frequent clinical characteristics of recurrent VS. Microsurgery or microsurgery followed by radiosurgery shows little difference in tumor control rate for primary and recurrent VS. However, radiosurgery alone appears to be less beneficial for recurrent VS.

Keywords

References

  1. Beatty CW, Ebersold MJ, Harner SG : Residual and recurrent acoustic neuromas. Laryngoscope 97 : 1168-1171, 1987
  2. Bloch DC, Oghalai JS, Jackler RK, Osofsky M, Pitts LH : The fate of the tumor remnant after less-than-complete acoustic neuroma resection. Otolaryngol Head Neck Surg 130 : 104-112, 2004 https://doi.org/10.1016/S0194-5998(03)01598-5
  3. Cerullo LJ, Grutsch J, Osterdock R : Recurrence of vestibular (acoustic) schwannomas in surgical patients where preservation of facial and cochlear nerve is the priority. Br J Neurosurg 12 : 547-552, 1998 https://doi.org/10.1080/02688699844402
  4. Charabi S, Tos M, Borgesen SE, Thomsen J : Cystic acoustic neuromas. Results of translarbyrinthine surgery. Arch Otolaryngol Head Neck Surg 120 : 1333-1338, 1994 https://doi.org/10.1001/archotol.1994.01880360031006
  5. Charabi S, Tos M, Thomsen J, Pygaard J, Fundova P, Charabi B : Cystic vestibular schwannoma : clinical and experimental studies. Acta Otolaryngol Suppl 543 : 11-13, 2000
  6. Darrouzet V, Martel J, Enee V, Bebear JP, Guerin J : Vestibular schwannoma surgery outcomes : our multidisciplinary experience in 400 cases over 17 years. Laryngoscope 114 : 681- 688, 2004 https://doi.org/10.1097/00005537-200404000-00016
  7. Ebersold MJ, Harner SG, Beatty CW, Harper CM Jr, Quast LM : Current results of the retrosigmoid approach to acoustic neurinoma. J Neurosurg 76 : 901-909, 1992 https://doi.org/10.3171/jns.1992.76.6.0901
  8. El-Kashlan HK, Zeitoun H, Arts HA, Hoff JT, Telian SA : Recurrence of acoustic neuroma after incomplete resection. Am J Otol 21 : 389- 92, 2000 https://doi.org/10.1016/S0196-0709(00)80049-6
  9. Fischer G, Fischer C, Remond J : Hearing preservation in acoustic neurinoma surgery. J Neurosurg 76 : 910-917, 1992 https://doi.org/10.3171/jns.1992.76.6.0910
  10. Fundova P, Charabi S, Tos M, Thomsen J : Cystic vestibular schwannomas : surgical outcome. J Laryngol Otol 114 : 935-939, 2000
  11. Gormley WB, Sekhar LN, Wright DC, Kamerer D, Schessel D : Acoustic neuromas : results of current surgical management. Neurosurgery 41 : 50-60, 1997 https://doi.org/10.1097/00006123-199707000-00012
  12. Hasegawa T, Kida Y, Kobayashi T, Yoshimoto M, Mori Y, Yoshida J : Long-term outcomes in patients with vestibular schwannoma treated using gamma knife surgery : 10-year follow up. J Neurosurg 102 : 10-16, 2005 https://doi.org/10.3171/jns.2005.102.1.0010
  13. Hong HJ, Yi HJ, Oh SJ, Ko Y : Cystic non-enhancing vestibular schwannoma with unusual clinical resentation. J Korean Neurosurg Soc 35 : 214-216, 2004
  14. Iwai Y, Yamanake K, Ishiguro T : Surgery combined with radiosurgery of larger acoustic neuromas. Surg Neurol 59 : 283-291, 2003
  15. Kameyama S, Tanaka R, Kawaguchi T, Fukuda M, Oyanagi K : Cystic acoustic neurinomas : studies of 14 cases. Acta Neurochir (Wien) 138 : 695-699, 1996 https://doi.org/10.1007/BF01411474
  16. Karpinos M, Teh BS, Zeck O, Carpenter LS, Phan C, Mai WY, et al : Treatment of acoustic neuroma : stereotactic radiosurgery vs. microsurgery. Int J Radiat Oncol Biol Phys 54 : 1410-1421, 2002 https://doi.org/10.1016/S0360-3016(02)03651-9
  17. Lee DJ, Westra WH, Staecker H, Long D, Niparko JK : Clinical and histopathologic features of recurrent vestibular schwannoma (acoustic neuroma) after stereotactic radiosurgery. Otol Neurotol 24 : 650-660, 2003 https://doi.org/10.1097/00129492-200307000-00020
  18. Lunsford LD, Niranjan A, Klickinger JC, Maitz A, Kondziolka D : Radiosurgery of vestibular schwannoma : summary of experience in 829 cases. J Neurosurg (Suppl) 102 : 195-199, 2005 https://doi.org/10.3171/jns.2005.102.s_supplement.0195
  19. Muzumdar DP, Goel A, Pakhmode CK : Multicystic acoustic neurinoma : report of two cases. J Clin Neurosci 9 : 453-455, 2002 https://doi.org/10.1054/jocn.2001.1003
  20. Pendl G, Ganz JC, Kitz K, Eustacchio S : Acoustic neurinomas with macrocysts treated with gamma knife radiosurgery. Stereotact Funct Neurosurg (Suppl 1) 66 : 103-111, 1996 https://doi.org/10.1159/000099775
  21. Pollock BE, Lunsford LD, Flickinger JC, Clyde BL, Kondziolka D : Vestibular schwannoma management. Part I. Failed microsurgery and the role of delayed stereotactic radiosurgery. J Neurosurg 89 : 944-948, 1998 https://doi.org/10.3171/jns.1998.89.6.0944
  22. Pollock BE, Lunsford LD, Kondziolka D, Sekula R, Subach BR, Foote RL, et al : Vestibular schwannoma management. Part II. Failed radiosurgery and the role of delayed microsurgery. J Neurosurg 89 : 949-955, 1998 https://doi.org/10.3171/jns.1998.89.6.0949
  23. Robertson JB Jr, Brackmann DE, Hitselberger WE : Acoustic neuroma recurrence after suboccipital resection : management with translabyrinthe resection. Am J Otol 17 : 307-311, 1996
  24. Sakaki S, Nakagawa K, Hatakeyama T, Murakami Y, Ohue S, Matsuoka K : Recurrence after incompletely resected acousticus neurinomas. Med J Osaka Univ 40 : 59-66, 1991
  25. Samii M, Matthies C : Management of 1000 vestibular schwannomas (acoustic neuromas) : surgical management and results with an emphasis on complications and how to avoid them. Neurosurgery 40 : 11-23, 1997 https://doi.org/10.1097/00006123-199701000-00002
  26. Sampath P, Holliday MJ, Brem H, Niparko JK, Long DM : Facial nerve injury in acoustic neuroma (vestibular schwannoma) surgery : etiology and prevention. J Neurosurg 87 : 60-66, 1997 https://doi.org/10.3171/jns.1997.87.1.0060
  27. Schessel DA, Nedzelski JM, Kassel EE, Rowed DW : Recurrence rates of acoustic neuroma in hearing preservation surgery. Am J Otol 13 : 233-235, 1992
  28. Slattery WH III, Brackmann DE : Results of surgery following stereotactic irradiation for acoustic neuromas. Am J Otol 16 : 315-321, 1995
  29. Sugimoto T, Tsutsumi T, Noguchi Y, Tsunoda A, Kitamura K, Komatsuzaki A : Relationship between cystic change and rotatory vertigo in patients with acoustic neuroma. Acta Otolaryngol Suppl. 542 : 9- 12, 2000
  30. Thomassin JM, Pellet W, Epron JP, Braccini F, Roche PH : Recurrent acoustic neurinoma after complete surgical resection. Ann Otolaryngol Chir Cervicofac 118 : 3-10, 2001
  31. Unger F, Walch C, Haselsberger K, Papaefthymiou G, Trummer M, Eustacchio S, et al : Radiosurgery of vestibular schwannoma : a minimally invasive alternative to microsurgery. Acta Neurochir (Wien) 141 : 1281- 1286, 1999 https://doi.org/10.1007/s007010050431
  32. Unger F, Walch C, Papaefthymiou G, Feichtinger K, Trummer M, Pendl G : Radiosurgery of residual and recurrent vestibular schwannoma. Acta Neurochir 144 : 671-677, 2002 https://doi.org/10.1007/s00701-002-0950-5
  33. Hwang SK, Kim DG, Paek SH, Kim CY, Kim MK, Choi JG, et al : Aggressive vestibular schwannomas with postoperative rapid growth : clinicopathological analysis of 15 cases. Neurosurgery 51 : 1381-1391, 2002 https://doi.org/10.1097/00006123-200212000-00008