Toxicological Research

  • 제22권4호
  • /
  • Pages.391-395
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  • 2006
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

Antioxidant and Cytotoxicity Effects of Luteolin

  • Park Jin-Ny (Division of Hematology/Oncology, Internal Medicine, Gachon University Gil Medical Center) ;
  • Kang Kyoung-Ah (Department of Biochemistry, College of Medicine, Cheju National University) ;
  • Zhang Rui (Department of Biochemistry, College of Medicine, Cheju National University) ;
  • Piao Mei Jing (Department of Biochemistry, College of Medicine, Cheju National University) ;
  • Park So-Yoon (Department of Pathology, College of Medicine, Cheju National University) ;
  • Kim Ju-Sun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kang Sam-Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Hyun Jin-Won (Department of Biochemistry, College of Medicine, Cheju National University)
  • 발행 : 2006.12.30
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초록

Flavonoids are polyphenolic compounds that are ubiquitous in plants. They have been shown to possess a variety of biological activities, such as antioxidant and anticancer. Reactive oxygen species (ROS) lead to damages of cellular molecules and it is the one of various factors to induce cancer. The one of flavonoids, Luteolin, was found to scavenge 1,1-diphenyl-2-piculhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). Moreover luteolin showed protection on hamster lung fibroblast cells (V79-4 cell) damage induced by $H_2O_2$. And then it was investigated whether it may show cytotoxicity effect against various cancer cells by MTT, Luteolin at $10{\mu}g/ml$ showed the cell viability of 63.2%, 34.7%, 18.4% and 71.4% against NCl-H460, HeLa, U937 and MCF-7, respectively. As a result, luteolin shows more sensitive to U937 cells among the tested cancer cell lines. In summary, luteolin has antioxidant and cytotoxicity effect or various cancer cell lines.

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참고문헌

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