Toxicological Research

  • 제22권4호
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  • Pages.333-338
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  • 2006
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

갈파래 추출 분획물의 CCl4 독성에 대한 항산화 효과

Anti-Oxidative Effects of Ulva lactuca Extract Fractions Against CCl4 Toxification

  • 남천석 (신라대학교 의생명과학대학 제약공학과) ;
  • 강금석 (신라대학교 의생명과학대학 제약공학과) ;
  • 하종명 (신라대학교 의생명과학대학 제약공학과) ;
  • 이상현 (신라대학교 의생명과학대학 제약공학과) ;
  • 이재화 (신라대학교 의생명과학대학 제약공학과) ;
  • 이동근 (신라대학교 의생명과학대학 제약공학과) ;
  • 장정수 (바이넥스 기업부설연구소) ;
  • 강환열 (아마란스 화장품) ;
  • 하배진 (신라대학교 의생명과학대학 제약공학과)
  • Nam, Chun-Suk (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Kang, Kum-Suk (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Ha, Jong-Myung (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Lee, Sang-Hyeon (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Lee, Jae-Hwa (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Lee, Dong-Geun (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) ;
  • Jang, Jeong-Su (Central Research Institute, Binex Co., Ltd.) ;
  • Kang, Hwan-Yul (Amaranth Cosmetics) ;
  • Ha, Bae-Jin (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University)
  • 발행 : 2006.12.30
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초록

This study was to investigate the preventive effects in anti-oxidation of Ulva lactuca extract fractions (ULEF) against $CCl_4$ toxification in liver total homogenate and mitochondrial fraction of ULEF-pretreated and carbon tetrachloride $(CCl_4)-posttreated$ rats. ULEF was intraperitoneally administered into rats at dose of 1 ml/kg for14 days. On the day 15, 3.3 ml/kg of $CCl_4$ dissolved in olive oil (1:1) was injected 12 hr before anesthetization. Activities of superoxide dismutase(SOD) in mitochondrial fraction were measured and catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA) in liver total homogenate. SOD, CAI and GPx were higher in the ULEF-pretreated and $CCl_4-posttreated$ group than those in the $CCl_4-posttreated$ group, and the pretreatment of ULEF decreased MDA. These results showed that the pretreatment of ULEF had the preventive role in the activities of anti-oxidative enzymes, SOD, CAT and GPx

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