Korean Journal of Community Nutrition (대한지역사회영양학회지)

The Korean Society of Community Nutrition (대한지역사회영양학회)
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Iron Nutritional Status by ALAD Genotype and Intervention Study for Rural Area Residents

농촌 여성들의 ALAD 유전형질별 철분영양상태와 철분제 섭취에 따른 영양상태의 변화

  • Kim, Hee-Seon (Department of Food Science and Nutrition. Soonchunhyang University) ;
  • Kim, Min-Kyung (Department of Food Science and Nutrition. Soonchunhyang University) ;
  • Kim, So-Hee (Asan Public Health Center) ;
  • Lee, Sung-Soo (Institute of Industrial Medicine, Soonchunhyang University) ;
  • Lee, Byung-Kook (Institute of Industrial Medicine, Soonchunhyang University)
  • 김희선 (순천향대학교 식품영양학과) ;
  • 김민경 (순천향대학교 식품영양학과) ;
  • 김소희 (아산시 보건소) ;
  • 이성수 (순천향대학교 산업의학연구소) ;
  • 이병국 (순천향대학교 산업의학연구소)
  • Published : 2006.12.31
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Abstract

Previous studies have suggested that delta-aminolevulinic acid dehydratase (ALAD) phenotype differently affect mineral metabolism. The objective of this study was to determine the effectiveness of 6-month iron supplementation as syrup of NaFeEDTA in improvement of iron status according to ALAD genotype. One hundred thirty adult women living in rural areas of Asan were provided NaFeEDTA syrup once a week for 6 months at the dose of 64mg Fe/week. Three hundred control subjects were observed during the study period. Fasting blood was obtained for analyzing hemoglobin (Hb) and zinc protophorphyrin (ZPP) and serum was analyzed for ferritin, iron and total iron capacity (TIBC) levels before and after iron supplementation. Ninety percent of ALAD 1-1 (ALAD1) and 10% of ALAD 1-2 (ALAD2) genotype were observed in the control group. However in the intervention group, 98% showed ALAD1 while only 2% was ALAD2, which is significantly lower proportions of ALAD2 compared to the control group (p<0.01). The iron status of Intervention group significantly improved except for ferritin and TIBC regardless or ALAD genotype, while the control group did not show any changes in iron status except for ZPP. ZPP concentration of the control group significantly increased in both ALAD1 and 2 while the intervention group showed significantly decreased ZPP after supplementation in ALAD1. Iron supplementation in the form of NaFeEDTA seems to be effective in reduction of ZPP levels although ALAD2 did not show significant changes due to the small number. However, it is difficult to make a conclusion from these results, and more specified further investigation is needed with more participants.

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References

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