Journal of Embryo Transfer (한국수정란이식학회지)

The Korean Society of Embryo Transfer (한국수정란이식학회)
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Association between Economic Traits and Candidate Gene Polymorphism in Korean Native Pig and Duroc

한국 재래 돼지와 듀록의 경제형질과 후보 유전자 다형성간의 연관성 분석

  • Kim, M.J. (National Livestock Research Institute, R.D.A.) ;
  • Oh, J.D. (Genomic Informatics Center, Hankyong National University) ;
  • Cho, G.H. (National Livestock Research Institute, R.D.A.) ;
  • Lee, J.H. (Genomic Informatics Center, Hankyong National University) ;
  • Lee, S.S. (National Livestock Research Institute, R.D.A.) ;
  • Hong, Y.S. (Genomic Informatics Center, Hankyong National University) ;
  • Jeon, K.J. (National Livestock Research Institute, R.D.A.) ;
  • Jeon, G.J. (Genomic Informatics Center, Hankyong National University) ;
  • Lee, H.K. (Genomic Informatics Center, Hankyong National University)
  • Published : 2006.12.31
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Abstract

MC4R, PRKAG3, FABP3, and ESR have reported as important candidate genes related to some economic traits in pigs. To investigate the association between these genes and economic traits, the analysis of restriction fragment length polymorphism (RFLP) was conducted on 147 individuals (96 Durocs and 86 Korea native pigs; KNP) using single nucleotide polymorphism (SNP). Different genotype frequencies of 4 candidate genes were observed in Duroc and KNP. There were significant associations between MC4R polymorphic site and average daily gain (ADG, p<0.05) and backfat thickness (BF, p<0.05) in the Duroc, ADG (p<0.05) and days to 70 kg (p<0.05) in KNP. PRXAG3 polymorphic site were significantly .elated to BF (p<0.05) in the Duroc, ADG (p<0.05) and days to 70 kg (p<0.05) in the KNP. In FABP3, association with BF (p<0.05) in the Duroc, ADG (p<0.05) and days to 70 kg (p<0.05) in the KNP were found. ESR polymorphic site was not significantly associated to any other traits.

본 연구는 후보 유전자의 경제형질에 미치는 염기 변이 효과를 검증하기 위해 국내에서 사육된 듀록 품종 96두와 한국 재래 돼지 86두를 활용하였다. 검증에 활용된 4개의 후보 유전자는 MC4R, PA-KAG3, FABP3 그리고 ESR 유전자였다. 각 후보 유전자들의 유전자형 분석 결과 두 집단 간에 유전적 특성의 차이가 분명히 나타나고 있음을 확인하였다. MC4R 유전자의 A 대립 유전자는 두 집단 모두에서 성장 형질과의 유의한 연관성이 검출되었고, 듀록 품종에서는 등지방 두께와도 관련이 있음을 확인하였다. PAKAG3 유전자의 B 대립 유전자는 듀록 품종의 등지방 두께와 재래 돼지 집단의 성장형질에서 유의성이 검출되었다. FABP3 유전자의 A 대립 유전자는 듀록 품종에서 등지방 두께, 재래 돼지 집단에서 성장 형질과의 연관성이 유의한 것으로 나타났다. 본 연구를 통해 얻어진 결과는 추가적인 분석을 통하여 선발 지수식에 적용을 한다면 우수한 개체를 선발하는데 있어 정확도를 높이는데 유용하게 활용될 것으로 사료되며 국내의 재래 품종들에 대한 유전 자원 보존과 개량을 위한 기초 자료로 유용하게 활용될 것으로 기대된다.

Keywords

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