Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Indoxacarb Pesticide Poisoning with Methemoglobinemia

메트헤모글로빈혈증을 보인 indoxacarb 중독 1례

  • Shin, Jae-Hoon (Departments of Emergency Medicine, Konyang University College of Medicine) ;
  • Lee, Jae-Kwang (Departments of Emergency Medicine, Konyang University College of Medicine) ;
  • Park, Seong-Soo (Departments of Emergency Medicine, Konyang University College of Medicine) ;
  • Na, Sang-Jun (Departments of Emergency Neurology, Konyang University College of Medicine) ;
  • Park, Joon-Seok (Departments of Emergency Medicine, Konyang University College of Medicine)
  • 신재훈 (건양대학교 의과대학 응급의학교실) ;
  • 이재광 (건양대학교 의과대학 응급의학교실) ;
  • 박성수 (건양대학교 의과대학 응급의학교실) ;
  • 나상준 (건양대학교 의과대학 신경과학교실) ;
  • 박준석 (건양대학교 의과대학 응급의학교실)
  • Published : 2006.12.31
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Abstract

Acute methemoglobinemia is induced by various causes, especially ingestion of oxidizing agents such as phenazopyridine, dapsone, and nitrite. Indoxacarb is an oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. It is known to block voltage-gated Na+ channels in insects and mammals, but the mechanism is not yet well understood. We describe a case of a 41-year-old woman with methemoglobinemia that developed following Indoxacarb ingestion, which improved after intravenous injection of methylene blue. This is the first known such case. If signs and symptoms of methemoglobinemia occur after Indoxacarb ingestion, antidotal therapy with methylene blue should be considered as a necessary treatment.

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