Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of Ginseng Radix Plus Crataegi Fructus on the Mice Model of Alzheimer's Disease

인삼산사복합방(人蔘山査複合方)이 Alzheimer성 치매의 병태(病態) 모델에 미치는 영향

  • Han, Sin-Hee (Department of Oriental Health Care, Joongbu University) ;
  • Kil, Gi-Jung (Department of Oriental Medicine Resources, Joongbu University)
  • 한신희 (중부대학교 한방건강관리학과) ;
  • 길기정 (중부대학교 한약자원학과)
  • Published : 2006.12.30
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Abstract

This research was investigated the effect of the Ginseng Radix plus Crataegi Fructus (Gin-CF) on Alzheimer's disease. Specifically, the effects of the Gin-CF extract on $IL-1\beta,\;TNF-\alpha$ of BV2 microglia cell line treated with LPS. The Gin-CF extract suppressed the over-expression of $IL-1\beta$ protein, $TNF-\alpha$ protein, MDA, and CD68/CD11b, in the mice with Alzheimer's disease induced by ${\beta}A$. These results suggest that the Gin-CF extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Gin-CF extract for Alzheimer's disease is suggested for future research.

Keywords

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