Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antigastritic and Anti Helicobacter pylori of Trifolirhizin from Sophora Radix

고삼 Trifolirhizin의 항위염 및 항 H. pylori 균 효과

  • Kang, Min-Hee (College of Pharmacy, Duksung Women's University) ;
  • Lee, Jung-Hun (College of Pharmacy, Duksung Women's University) ;
  • Lee, Je-Hyuk (Plant Resources Research Institute, Duksung Women's University) ;
  • Cho, So-Yean (Division of Herbal Medicines Standardization, Korea Food & Drug Administration) ;
  • Choi, Jae-Sue (Faculty of Food Science and Biotechnology, Pukyong National University) ;
  • Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Jeong, Choon-Sik (College of Pharmacy, Duksung Women's University)
  • 강민희 (덕성여자대학교 약학대학) ;
  • 이정헌 (덕성여자대학교 약학대학) ;
  • 이제혁 (덕성여자대학교 식물자원연구소) ;
  • 조소연 (식품의약품안전청 생약규격팀) ;
  • 최재수 (부경대학교 식품공학부) ;
  • 김영식 (서울대학교 약학대학 천연물과학연구소) ;
  • 강삼식 (서울대학교 약학대학 천연물과학연구소) ;
  • 정춘식 (덕성여자대학교 약학대학)
  • Published : 2006.12.30
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Abstract

Sophorae Radix, the dried roots of Sophora flavescens Aiton (Leguminosae), has been used in oriental traditional medicine for treatment of skin and mucosal ulcers, sores, gastrointestinal hemorrhage, diarrhea, inflammation and arrhythmia. Present study was carried out for the gastroprotective effect of trifolirhizin from Sophora flavescens. This reports were evaluated antibacterial activity against Helicobacter pylori and HCl ethanol-induced gastric lesion in rats and showed the significant effectiveness. In pylorus ligated rats, the treatments of trifolirhizin showed decrease in the volume of gastric secretion and acid output. Also we evaluated the antibacterial activity against H. pylori treated with methanol extract and trifolirhizin from Sophora flavescens had a equivalent antibacterial activity with ampicillin against H. pylori at the dose of $100{\mu}g/mL$. It may be regarded that the antigastritic effects and antibacterial activity of trifolirhizin from Sophora flavescens are originated from reduction of total acid output identified by gastric secretion reduce, free radical scavenging effects and the antibacterial activity against H. pylori.

Keywords

References

  1. Uccheddu, A., Floris, G, Altana, M. L., Pisanu, A., Cois, A. and Farci, S. L. (2003) Surgery for perforated peptic ulcer in the elderly. Evaluation of factors influencing prognosis. Hepatogastroenterology 50: 1956-1958
  2. Shay, H., Komarov, S. A., Fels, S. S., Meranze, D., Gruenstein, M. and Siplet, H. (1945) A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol 4: 43
  3. Yoshida, N., Yoshikawa, T., Iinuma, S., Arai, M., Takenaka, S., Sakamoto, K., Miyajima, T., Nakamura, Y, Yagi, N., Naito, Y, Mukai, F. and Kondo, M. (1996) Rebamipide protects against activation of neutrophils by Helicobacter pylori. Dig. Dis. Sci. 41: 1139-1144 https://doi.org/10.1007/BF02088229
  4. Leunk, R. D., Johnson, P. T., David, B. C, Kraft, W. G and Morgan, D. R. (1988) Cytotoxic activity in broth-culture filtrates of Campylobacter pylori. J. Med. Microbiol 26: 93-99 https://doi.org/10.1099/00222615-26-2-93
  5. Bae, E. A., Han, M. J., Baek, N. I. and Kim, D. H. (2001) In vitro anti Helicobacter pyloriactivity of panaxtriol isolated from ginseng. Arch. Pharm. Res. 24: 297-299 https://doi.org/10.1007/BF02975095
  6. 육창수, 김성만, 정진모, 정명숙, 깅정화, 김승배 (1995) 한약의 약리성분, 임상응용, 414-416. 계측문화사, 서울
  7. Jung, H. J., Kang, S. S., Woo, J. J. and Choi, J. S. (2005) A new lavandulylated flavonoid with free radical and $ONOO^{-}$ scavenging activities from Sophora flavescens. Arch. Pharm. Res. 28: 1333-1336 https://doi.org/10.1007/BF02977897
  8. Kim, Y C, Kim, H. S., Wataya, Y, Sohn, D. H., Kang, T. H., Kim, M. S, Kim, Y. M, Lee, G .M, Chang, J. D. and Park, H. (2004) Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens. Biol. Pharm. Bull. 27: 748-750 https://doi.org/10.1248/bpb.27.748
  9. Kim, H. A., You, H. K, Shin, H. S., Kim, Y C, Kang, T. H., Yu, H. H. and You, Y O. (2003) Effects of aqueous extract of Sophora flavescens on the expression of cell cycle regulatory proteins in human oral mucosal fibroblasts. Am. J. Chin. Med. 31: 563-572 https://doi.org/10.1142/S0192415X03001260
  10. Son, J. K., Park, J. S., Kim, J. A., Kim, Y, Chung, S. R. and Lee, S. H. (2003) Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med. 69: 559-561 https://doi.org/10.1055/s-2003-40643
  11. 조훈, 원성란, 양은영, 김종수, 유일수, 류도곤, 이정호, 강길웅, 백승화 (1999) 고삼추출물의 항균효과(I), 약학회지 43: 419-422
  12. 한국약학대학협의회약전분과회편저 (2003) 대한약전 제 8개정 해설서, 264-265. 문성사, 서울
  13. Uchiyama, M., Suzuki, Y. and Fukuzawa, K. (1968) Biochemical studies of physiological function of tocopherolactone. Yakugaku Zasshi 88: 678-683 https://doi.org/10.1248/yakushi1947.88.6_678
  14. Kim, J. M, Shin, J. E, Han, M. J, Baek, N. I. and Kim, D. H. (2003) Inhibitory Effect of Ginseng Polyacetylenes on Infection and Vacuolation of Helicobacter pylori. Natural Product Science 9: 158-160
  15. Mizui, T. and Dodeuchi, M. (1983) Effect of polyamines on acidified ethanol induced gastric lesion in rats. Jpn. J. Pharmacol. 33: 939-945 https://doi.org/10.1254/jjp.33.939
  16. Ito, M., Shii, D., Segami, T., Kojima, R. and Suzuki, Y. (1992) Preventive actions of Z-103 through increase in the activities of oxygen-derived free radical scavenging enzymes in the gastric mucosa on ethanol-induced gastric mucosal damage in rats. Jpn. J. Pharmacol. 59: 267-274 https://doi.org/10.1254/jjp.59.267