Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Hepatoprotective Effects of Brassica rapa (Turnip) on d-Galactosamine Induced Liver Injured Rats

순무의 d-galactosamine 유발 간장해 보호효과

  • Choi, Hyuck-Jae (East-West Medical Research Institute, Kyung Hee University) ;
  • Han, Myung-Joo (Department of Food and Nutrition, Kyung Hee University) ;
  • Baek, Nam-In (Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University) ;
  • Jung, Hae-Gon (Ganghwa Argicultural R&D Center) ;
  • Kim, Nam-Jae (East-West Medical Research Institute, Kyung Hee University)
  • 최혁재 (경희대학교 동서의학연구소) ;
  • 한명주 (경희대학교 식품영양학과) ;
  • 백남인 (경희대학교 생명공학원 및 식물대사센타) ;
  • 김동현 (경희대학교 약학대학) ;
  • 정해곤 (강화농업기술센타) ;
  • 김남재 (경희대학교 동서의학연구소)
  • Published : 2006.12.30
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Abstract

Brassica rapa L. (Turnip) which is one of the specialized crops in Ganghwa island, has been used for diuretic, digestive, and curative for jaundice, etc. In this study, the anti oxidative effects and hepatoprotective effects of turnip in vitro and in vivo were investigated in order to evaluate the possibility as hepatoprotective agents. Ethanol extract of turnip potently showed the scavenging effect on DPPH and inhibitory effect on lipid peroxidation. Oral administration of turnip extract to dgalactosamine-induced experimental liver injured rats was significantly reduced the serum AST, ALT and LDH enzyme activities. And the decrease of catalase and SOD activities in liver microsolmal cytosol was significantly improved by the treatment of turnip. Based on these findings, it is presumed that ethanol extract of turnip may have the hepatoprotective effect on d-galactosamine-induced hepatotoxicity rat.

Keywords

References

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