Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Phellinus baumii Inhibits Immediate-type Allergic Reactions

  • Shin, Tae-Yong (Dept. of Pharmacy, College of Pharmacy, Woosuk University) ;
  • Shin, Hye-Young (Dept. of Pharmacy, College of Pharmacy, Woosuk University) ;
  • Kim, Sang-Hyun (Dept. of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Kim, Dae-Keun (Dept. of Pharmacy, College of Pharmacy, Woosuk University) ;
  • Chae, Byeong-Suk (Dept. of Pharmacy, College of Pharmacy, Woosuk University) ;
  • Oh, Chan-Ho (Dept. of Food Biotechnology, Woosuk University) ;
  • Cho, Moon-Gu (Dept. of Food Biotechnology, Woosuk University) ;
  • Oh, Suk-Heung (Dept. of Food Biotechnology, Woosuk University) ;
  • Kim, Jong-Hwa (Dept. of Pharmaceutical Engineering, Woosuk University) ;
  • Lee, Tae-Kyoo (Dept. of Food Industry & Management, Woosuk University) ;
  • Park, Jeong-Suk (Dept. of Oriental Alternative Medicine, Nambu University) ;
  • Kim, Sang-Yong (Division of Specimen and Genetic Resources, Korea National Arboretum)
  • Published : 2006.12.30
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Abstract

In this study, we investigated the effect of Phellinus baumii (PB) on immediate-type allergic reaction and inflammatory cytokine secretion. PB inhibited compound 48/80-induced systemic reactions in mice. PB inhibited compound 48/80-induced plasma histamine release. In addition, PB also inhibited the immunoglobulin (Ig) E-mediated local allergic reaction. Furthermore, PB decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis $factor-\alpha$ and interleukin-6 secretion in human mast cells. These results indicate that PB may be beneficial in the treatment of immediate-type allergic reactions.

Keywords

References

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