대한의생명과학회지 (Biomedical Science Letters)
- 제12권4호
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- Pages.457-461
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- 2006
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Anticancer Effect of Ferulic Acid on Cultured Human Skin Melanoma Cells
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- 손영우 (원광대학교 의과대학 산본병원)
- Son, Byoung-Kwan (Sanbon Medical Center, Wonkwang University) ;
- Choi, Yu-Sun (Sanbon Medical Center, Wonkwang University) ;
- Sohn, Young-Woo (Sanbon Medical Center, Wonkwang University)
- 발행 : 2006.12.31
초록
It is demonstrated that phenolic compound has cytotoxic effect on cancer cells. Recently, ferulic acid is involved in anticancer activity by showing the decrease of cell viability in cancer cells. But, the anticancer mechanism of ferulic acid is left unknown. The purpose of this study was to examine the anticancer activity of ferulic acid on NIH3T3 fibroblasts and human skin melanoma cells (SK-MEL-3). The anticancer activity was measured by determining the cytotoxicy of ferulic acid on these cells. The cytotoxicity was measured by cell viability via XTT assay in these cells. In this study, ferulic acid decreased cell viability according to the dose-dependent manners after human skin melanoma cells were treated with various concentrations of ferulic acid for 48 hours. especially, ferulic acid remarkably decreased cell viability at a concentration of