Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Relaxative Effect of Transmural Nerve Stimulation via ${\beta}$-adrenergic Nerve on the Isolated Uterine Smooth Muscle Motility of Pigs

돼지 적출 자궁 평활근의 운동성에 있어서 transmural nerve stimulation에 대한 ${\beta}$-adrenergic 신경의 이완작용

  • Kim, Joo-Heon (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Jeon, Jae-Cheul (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Rho, Gyu-Jin (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Hong, Yong-Geun (Cardiovascular & Metabolic Disease Center College of Biomedical Science and Engineering, Inje University) ;
  • Choe, Sang-Yong (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • 김주헌 (경상대학교 수의과대학, 동물의학연구소) ;
  • 전제철 (경상대학교 수의과대학, 동물의학연구소) ;
  • 노규진 (경상대학교 수의과대학, 동물의학연구소) ;
  • 홍용근 (인제대학교 의생명공학대학, 심혈관 및 대사성질환 센터) ;
  • 최상용 (경상대학교 수의과대학, 동물의학연구소)
  • Published : 2006.12.30
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Abstract

The effects of transmural nerve stimulation induced releasing neurotransmitters on the changes of swine uterine smooth muscle motility were examined by polygraph through isometric force transducer. The frequency dependent relaxation and rebound contraction were revealed on precontraction with histamine by transmural nerve stimulation. The rebound contraction by transmural nerve stimulation was inhibited by nonselective ${\alpha}$-adrenergic receptor antagonist, phentolamine, and the relaxation by transmural nerve stimulation was blocked by nonselective ${\beta}$-adrenergic receptor antagonist, propranolol. The relaxation induced by nonselective ${\beta}$-adrenergic receptor agonist, isoproterenol on precontraction with histamine were the dose dependent manner and this relaxation was blocked by nonselective ${\beta}$-adrenergic receptor antagonist, propranolol in isolated uterine smooth muscle of pig. These results suggest that endogenous neurotransmitters on smooth muscle relaxation was influenced by ${\beta}$-adrenergic receptor in swine.

Keywords

References

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