The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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The Effects of Radix Scrophulariae (玄蔘) on the Hyperthyroidism of Rats

현삼이 갑상선기능항진 유발 백서에 미치는 영향

  • Park, Chan-Uk (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Kim, Cheol-Jung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University) ;
  • Cho, Chung-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
  • 박찬욱 (대전대학교 한의과대학 신계내과학교실) ;
  • 김철중 (대전대학교 한의과대학 신계내과학교실) ;
  • 조충식 (대전대학교 한의과대학 신계내과학교실)
  • Published : 2006.09.30
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Abstract

Objective: The aim was to study experimentally the effects of Radix Scrophulariae (玄蔘) induced by Sodium levothyroxine. Methods: Sprague-Dawley rats Were separated into four groups. Except for the normal group, the other three were treated with sodium levothyroxine $160{\mu}g/kg$ for 5 days. Among the three groups, two (except the control) were treated with Radix Scrophulariae extract 0.5g/kg (HNS 1) or 1.0g/kg (HNS II). $T_3-uptake,\;T_3,\;T_4$, TSH, total cholesterol, glucose, ALP, AST, ALT, free fatty acid, $\beta-lipoprotein$, and change in the serum of rats were measured after medication of solid extract of Radix Scrophulariae. Results: As a result of this study, HNS II showed significant decrease in comparison with the control in the serum $T_3-uptake,\;T_3$ ALP and free fatty acid content. HNS I and HNS II showed significant decrease in comparison with the control in the serum of $T_4$ and glucose content. HNS I and HNS II showed significant increase in comparison with the control in the serum of TSH and total cholesterol content. In body weight, HNS I and HNS II showed significant increase in comparison with the control. Conclusion: These results suggest that Radix Scrophulariae is effective to cure hyperthyroidism.

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