Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Effects of Estrogen, Aging and Oxidative Stress on Bone Remodelling in a View of Molecular Mechanisms

골개형(Bone Remodelling)의 분자생물학적 기전에 대한 노화, 에스트로젠 및 산화적 스트레스의 영향

  • Park, Yeong-Chul (Center for Bio-Safety Catholic University of Daegu) ;
  • Koh, Young-Do (Department of Orthopaedic Surgery, Medical College, Ewha Women University) ;
  • Han, Jung-Ho (Medical Research Center, Seoul National University) ;
  • Kim, Mi-Kyung (Marine Science Research Center, Yeungnam University)
  • 박영철 (대구가톨릭대학교 바이오안전성센터) ;
  • 고영도 (이화여자대학교 의과대학 정형외과(목동병원)) ;
  • 한정호 (서울대학교 의학연구원) ;
  • 김미경 (영남대학교 해양과학연구센터)
  • Published : 2006.09.30
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Abstract

Bone is a dynamic tissue that is constantly being remodelled. Resolution of bone and formation of new bone are closely linked, so that bone mass remains constant. With age, this process becomes unlinked with an imbalance in bore resorption and formation that results in a net loss of bone. Especially, osteoporosis is a disease characterized by low bone mass with age. One form of aging-related primary osteoporosis is postulated with the reduction of circulating estrogen, rapid bone loss occurs as a result of enhanced bore remodelling with an excess of resorption over bore formation. The oxidative stress is also involved in the pathogenesis of osteoporosis. Oxidative stress by cytokines, such as IL-a and TNF-${\alpha}$, inhibits osteoblast function in vitro and stimulates osteoblast apoptosis resulting in an imbalance in bore remodelling. The present article reviews the current perspectives on the interaction between bone remodelling and factors such as estrogen and oxidative stress, providing an interpretation of bone diseases in a view of molecular mechanisms.

Keywords

References

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