Toxicological Research

  • 제22권3호
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  • Pages.237-244
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  • 2006
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

랫드에 주입된 세피오라이트에 의한 호흡기독성 연구

A Respiratory Toxicity Study of Sepiolite in Sprague-Dawley Rats

  • 정용현 (산업안전보건연구원 화학물질안전보건센터) ;
  • 한정희 (산업안전보건연구원 화학물질안전보건센터) ;
  • 성재혁 (한국생활환경시험연구원) ;
  • 유일재 (한국생활환경시험연구원)
  • Chung, Yong-Hyun (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Han, Jeong-Hee (Chemical Safety and Health Research Center, Occupational Safety & Health Research Institute) ;
  • Sung, Jae-Hyuck (Korean Environment & Merchandise Testing Institute) ;
  • Yu, Il-Je (Korean Environment & Merchandise Testing Institute)
  • 발행 : 2006.09.30
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초록

Two kinds of sepiolite, a $500^{\circ}C$ heat-treated sepiolite, and a $700^{\circ}C$ heat-treated sepiolite were analyzed for their physicochemical properties. After these sepiolites were instilled into rat lungs, the effects of the substances on lung pathological changes were evaluated. The lungs instilled with sepiolite increased their weight compared with the unexposed control. The pathological examination further showed increased legions of granuloma with early fibrosis. The heat treated sepiolites, however, did not show any toxicological differences from the untreated sepiolites. Thus chronic experiments are needed to evaluate the durability of mineral fibers, which is an essential experiment for evaluating biopersistence of fibers in lungs.

키워드

참고문헌

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