Journal of the Optical Society of Korea

  • 제10권3호
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  • Pages.99-104
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  • 2006
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  • 1226-4776(pISSN)
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  • 2093-6885(eISSN)
한국광학회 (Optical Society of Korea)
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Nanoparticle Contrast in Magneto-Motive Optical Doppler Tomography

  • Kim, Jee-Hyun (Beckman Laser Institute and Medical Clinic, University of California) ;
  • Oh, Jung-Hwan (Biomedical Engineering Department, University of Texas)
  • 투고 : 2006.07.11
  • 발행 : 2006.09.25
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초록

We introduce a novel contrast mechanism for imaging superparamagnetic iron oxide (SPIO) nanoparticles (average diameter ${\sim}100nm$) using magneto-motive optical Doppler tomography (MM-ODT), which combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect the nanoparticles flowing through a glass capillary tube. A solenoid cone-shaped ferrite core extensively increased the magnetic field strength ($B_{max}=1\;T,\;{\Delta}|B|^2=220T^2/m$) at the tip of the core and also focused the magnetic force on targeted samples. Nanoparticle contrast was demonstrated in a capillary tube filled with the SPIO solution by imaging the Doppler frequency shift which was observed independent of the flow rate and direction. Results suggest that MM-ODT may be a promising technique to enhance SPIO nanoparticle contrast for imaging fluid flow.

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