CENTRAL GRANULAR CELL ODONTOGENIC TUMOR(CGCOT): A CASE REPORT INCLUDING LIGHT MICROSCOPY, IMMUNOHISTOCHEMISTRY AND LITERATURE REVIEW

상악 구치부에 발생한 Central Granular Cell Odontogenic Tumor(CGCOT)의 치험례

  • Kim, Jin-Wook (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Kyung-Pook National University) ;
  • Park, In-Suk (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Kyung-Pook National University) ;
  • Byeon, Gi-Jeong (Dept. of Dentistry, Ulsan University Hospital) ;
  • Kim, Chin-Soo (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Kyung-Pook National University)
  • 김진욱 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 박인숙 (경북대학교 치과대학 구강악안면외과학교실) ;
  • 변기정 (울산대학교병원 치과학교실) ;
  • 김진수 (경북대학교 치과대학 구강악안면외과학교실)
  • Published : 2006.08.31

Abstract

Central granular cell odontogenic tumor(CGCOT) is a very rare lesion that consists of densely packed granular cells with numerous scattered strands of odontogenic epithelium interspersed throughout the tissue. CGCOT was initially reported in 1962 by Cough et al as central granular cell ameloblastic fibroma. But, recently, this term is inappropriate because of histologic and chronologic differences. CGCOT is usually present as painless swellings. Radiographs show a well-demarcated radiolucent or mixed radiopaque-radiolucent lesion. The average age on presentation of CGCOT is 47.3 and women are 75% more likely to develop this lesion than men. The tumor only occur in tooth bearing areas of the jaw with 88% of cases occurring in the mandible and 12% involving the maxilla, usually in an equal distribution between the caninepremolar-molar areas. This tumor is benign, and care is effected by localized surgical excision. We report an additional case of CGCOT that occurred in the Rt. Maxillar premolar/molar region of a 32-year old man with literature review.

Keywords

References

  1. Werthemann A: Uber spongiozytares Adamantinom. Oncologia 1950;3:193-207 https://doi.org/10.1159/000223592
  2. Brannon RB, Goode RK, Eversole LR, et al.: The central granular cell odontogenic tumor: Report of 5 new cases. Oral Surg Oral Med Oral Pathol Oral Rdiol Endod 2002;94:614-21 https://doi.org/10.1067/moe.2002.126890
  3. Kramer IRH, Pindborg JJ, Shear M: Histological typing of odontogenic tumors(ed2). Heidelberg, Germany, Springer-verlag 1992
  4. Machado de Sousa SO, Soares de Araujo N, Melhado RM, Cavalcanti de Araujo V. Central odontogenic granular cell tumor: immunohistochemical study of two cases. J Oral Maxillofac Surg 1998;56:787-91 https://doi.org/10.1016/S0278-2391(98)90821-7
  5. Gesek DJ JR, Adrian JC, Reid EN: Central odontogenic granular cell tumor : a case report including light microscopy, immunohistochemistry, and literature review. J Oral Maxillofac Surg 1995;53:945-9 https://doi.org/10.1016/0278-2391(95)90290-2
  6. Ardekian L, Manor R, Gaspar R, Laufer D: Central granular cell odontgenic tumor: case report and review of literature. J Oral Maxillofac Surg 1998;56:1343-5 https://doi.org/10.1016/S0278-2391(98)90619-X
  7. Meer S, Altini M, Coleman H, Daya N: Central granular cell odontogenic tumor: Immunohistochemistry and ultrastructure. Am J Otolaryngol 2004;25;73-8 https://doi.org/10.1016/j.amjoto.2003.09.002
  8. Yih WY, Thompson C, Meshul CK, Bartley MH: Central odontogenic granular cell tumor of the jaw: report of case and immunohistochemical and electron microscopic study. J Oral Maxillofac Surg 1995;53:453-9 https://doi.org/10.1016/0278-2391(95)90723-8
  9. Vincent SD, Hammond HL, Ellis GL, Juhlin JP: Central granular cell odontogenic fibroma. Oral Surg Oral Med Oral Pathol 1987;63:715- 21 https://doi.org/10.1016/0030-4220(87)90376-8
  10. White DK, Chen SY, Hartman KS, Miller AS, Gomez LF: Central granular cell odontogenic tumor of the jaw(the so-called granular cell ameloblastic fibroma). Oral Surg Oral Med Oral Pathol 1978;45:396- 405 https://doi.org/10.1016/0030-4220(78)90525-X
  11. Gardner DG: Central odontogenic fibroma current concepts. J Oral Pathol Med 1989;25:556-61 https://doi.org/10.1111/j.1600-0714.1996.tb01731.x
  12. Chen SY: Central granular cell tumor of the jaw. An electron microscopic and immunohistochemical study. Oral Surg Oral Med Oral Pathol 1991;72:75-81 https://doi.org/10.1016/0030-4220(91)90193-G
  13. Ruhl GH, Akuamoa-Boateng E: Grnular cells in odontogenic and non odontogenic fibroma. Virchows Arch A Pathol Anat Histopathol 1989;415:403-9 https://doi.org/10.1007/BF00747741