Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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IMMUNOHISTOCHEMICAL STUDY ON EXPRESSION OF MMP-2 AND MMP-9 IN IRRITATION FIBROMA, ORAL LEUKOPLAKIA AND ORAL SQUAMOUS CELL CARCINOMA

자극성 섬유종, 구강백반증 및 구강편평세포암종에서 MMP-2 및 MMP-9 발현에 대한 면역조직화학적 연구

  • Kim, Moon-Key (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Lee, Eun-Ha (Department of Oral Pathology, College of Dentistry, Yonsei University) ;
  • Kim, Jin (Department of Oral Pathology, College of Dentistry, Yonsei University) ;
  • Lee, Eui-Woong (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Cha, In-Ho (Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University)
  • 김문기 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 이은하 (연세대학교 치과대학 구강병리학교실) ;
  • 김진 (연세대학교 치과대학 구강병리학교실) ;
  • 이의웅 (연세대학교 치과대학 구강악안면외과학교실) ;
  • 차인호 (연세대학교 치과대학 구강악안면외과학교실)
  • Published : 2006.08.31
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Abstract

MMP-2 and MMP-9, type IV collagenases which degrade basement membrane, have been known to play important roles in invasion and metastasis of tumor cells, In addition, they seem to be involved in cell differentiation, apoptosis, angiogenesis and immunity, etc. We immunohistochemically examined epithelial and stromal expressions of MMP-2 and MMP-9 in irritation fibroma, oral leukoplakia, and oral squamous cell carcinoma (OSCC) and have some results as follows: 1. Irritation fibromas, oral leukoplakias and OSCCs mostly showed increased expression of MMP-2 and MMP-9 in the epithelium and connective tissue compared with normal mucosa. 2. There was a significant difference in the epithelial expression of MMP-2 and MMP-9 between irritation fibroma and oral leukoplakia. 3. There was a significant difference in the epithelial and stromal expression of MMP-2 and MMP-9 between irritation fibroma and OSCC. 4. There was a significant difference in the stromal expression of MMP-9 between oral leukoplakia and OSCC. We concluded that rritation fibroma, oral leukoplakia and OSCC have somewhat different characteristics of MMP-2 and MMP-9 expressions, which perhaps result from different pathogenesis.

Keywords

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