Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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THE EXPRESSION OF FGF-5 AND FGF-7 IN THE CYCLOSPORIN A-INDUCED GINGIVAL HYPERPLASIA

Cyclosporin A에 의한 치은 증식증에서 FGF-5와 FGF-7의 발현 양상에 대한 연구

  • Jeong, Mi-Hyang (Dept. of Orthodontics, College of Dentistry, Seoul National University) ;
  • Kim, Seong-Gon (Dept. of Oral and Maxillofacial Surgery, College of Medicine, Hallym University) ;
  • Yun, Kyoung-In (Dept. of Oral and Maxillofacial Surgery, College of Medicine, Eulji University) ;
  • Nahm, Dong-Seok (Dept. of Orthodontics, College of Dentistry, Seoul National University)
  • 정미향 (서울대학교 치과대학 치과교정과) ;
  • 김성곤 (한림대학교 의과대학 성심병원 구강악안면외과) ;
  • 윤경인 (을지의과대학교 을지병원 구강악안면외과) ;
  • 남동석 (서울대학교 치과대학 치과교정과)
  • Published : 2006.06.30
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Abstract

Cyclosporin A-induced gingival hyperplasia is frequently found in the patients who have been received an immunosuppressant for the organ transplantation. However, its exact mechanism is still unknown. The expression of FGF-5 and FGF-7 were studied in cyclosporine A-induced gingival hyperplasia (CGH) and inflammatory gingival hyperplasia (IGH). Immunohistochemistry and in situ hybridization were used for localization of protein and mRNA. The expression of FGF-5 and FGF-7 was different from CGH and IGH. FGF-5 and FGF-7 was strongly expressed in fibroblast in CGH (P<0.005 and P<0.05, respectively). FGF-5 mRNA was localized in the middle portion of connective tissue. FGF-7 mRNA was also identified in fibroblasts and mast cells. In conclusion, FGF-5 and FGF-7 were produced excessively by fibroblasts in CGH. Considering their known functions, their expression in CGH is important for production of collagen and proliferation of fibroblasts.

Keywords

References

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