Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Assessment of antibacterial activity of the cardiovascular drug nifedipine

  • Pal, Tapas (Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Dutta, Noton Kumar (Division of Microbiology, Institute of Genetic Engineering, Kalyani University) ;
  • Mazumdar, Kaushiki (Division of Microbiology, Institute of Genetic Engineering, Kalyani University) ;
  • Dasgupta, Asish (Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • L., Jeyaseeli (Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Dastidar, Sujata G. (Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University)
  • Published : 2006.06.30
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Abstract

The cardiovascular drug nifedipine exhibited significant in vitro and in vivo antibacterial activity against 331 strains of bacteria belonging to three Gram-positive and twelve Gram-negative genera. The minimum inhibitory concentration of the drug, as determined both by agar and broth dilution methods, was seen to range from $25\;-\;200\;{\mu}g/ml$ against most test bacteria, including several pathogenic ones, in the in vitro studies. Nifedipine was bacteriostatic in action. in vivo studies with this drug showed that it could offer statistically significant protection (P < 0.001) to mice challenged with a virulent bacterium. Therefore, nifedipine has the potential of an antibacterial agent, which may be developed after further pharmacological studies.

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References

  1. Amaral L, Lorian V. (1991) Effects of chlorpromazine on the cell envelope proteins of Escherichia coli. Antimicrob. Agents Chemother. 35, 1923-1924.
  2. Annadurai S, Basu S, Ray S, Dastidar SG, Chakrabarty AN. (1998) Antimicrobial activity of the antiinflammatory agent diclofenac sodium. Indian J. Exp. Biol. 36, 86-90.
  3. Annadurai S, Guha Thakurta A, Sa B, Dastidar SG, Ray R, Chakrabarty AN. (2002) Experimental studies on synergism between aminoglycosides and the antimicrobial antiinflammatory agent diclofenac sodium. J. Chemother. 14, 47-53.
  4. Asok Kumar K, Ganguly K, Mazumdar K, Dutta NK, Dastidar SG, Chakrabarty AN. (2003) Amlodipine: a cardiovascular drug with powerful antimicrobial property. Acta Microbiol. Pol. 52, 285-292.
  5. Barrow GI, Feltham RKA. (1993) Cowan and Steel's Manual for the identification of medical bacteria, Cambridge University Press, Cambridge, UK.
  6. Bourlioux P, Moreaux JM, Su WJ, Boureau H. (1992) In vitro antimicrobial activity of 18 phenothiazine derivatives, structure-activity relationship. Acta Pathol. Microbiol. Immun. Scand. 100, 40-43.
  7. Chakrabarty AN, Acharya DP, Niyogi DK, Dastidar SG. (1989) Drug interaction of some non-conventional antimicrobial chemotherapeutic agents with special reference to promethazine. Indian J. Med. Res. 89, 233-237.
  8. Chattopadhyay D, Dastidar SG, Chakrabarty AN. (1998) Antimicrobial property of methdilazine and its synergism with antibiotics and some chemotherapeutic agents. Arzneimittelforschung 38, 869-872.
  9. Dash SK, Dastidar SG, Chakrabarty AN. (1977) Antimicrobial activity of promazine hydrochloride. Indian J. Exp. Biol. 15, 324-326.
  10. Dastidar SG, Annadurai S, Kumar KA, Dutta NK, Chakrabarty AN. (2003) Evaluation of a synergistic combination between the no-antibiotic microbicides diclofenac and trifluoperazine. Int. J. Antimicrob. Agents 21, 599-601. https://doi.org/10.1016/S0924-8579(03)00064-5
  11. Dastidar SG, Chaudhury A, Annadurai S, Roy S, Mookherjee M, Chakrabarty AN. (1995) In vitro and in vivo antimicrobial action of fluphenazine. J. Chemother. 7, 201-206.
  12. Dastidar SG, Ganguly K, Chaudhuri K, Chakrabarty AN. (2000) The antibacterial action of diclofenac shown by inhibition of DNA synthesis. Int. J. Antimicrob. Agents 14, 249-251. https://doi.org/10.1016/S0924-8579(99)00159-4
  13. Dastidar SG, Jairaj J, Mookherjee M, Chakrabarty AN. (1997) Studies on antimicrobial effect of the antihistaminic phenothiazine trimeprazine tartarate. Acta Microbiol. Immun. Hung. 44, 241-247.
  14. Dastidar SG, Mondal U, Niyogi S, Chakrabarty AN. (1986) Antibacterial property of methyl-DOPA and development of cross-resistance in m-DOPA mutants. Indian J. Med. Res. 84, 142-147.
  15. Dastidar SG, Saha PK, Sanyamat B, Chakrabarty AN. (1976) Antibacterial activities of ambodryl and benadryl. J. Appl. Bact. 41, 209-214.
  16. Karak P, K Asok Kumar, Basu LR, Dasgupta A, Ray R, Dastidar SG. (2004) Experimental analysis of antimicrobial action of dicyclomine hydrochloride. Biol. Pharm. Bull. 27, 2010-2013. https://doi.org/10.1248/bpb.27.2010
  17. Karak P, Kumar KA, Mazumdar K, Mookerjee M, Dastidar SG. (2003) Antibacterial potential of an antispasmodic drug dicyclomine hydrochloride. Indian J. Med. Res. 118, 192-196.
  18. Koneman EW, Allen SD, Janda WM, Schreckenberger PC, Winn WC Jr. (1997) (Eds.) Colour Atlas and Textbook of Diagnostic Microbiology, 5th ed, Lippincott, USA.
  19. Kristiansen JE. (1992) The antimicrobial activity of non-antibiotics. Acta Path. Microbiol. Scand. 100, 7-19.
  20. Krogstad DJ, Moellering RC. (1990) Combinations of Antibiotics, Mechanisms of Interaction against Bacteria, Chapter 11. In: Antibiotics in Laboratory Medicine, Lorian V (Ed.), Williams and Wilkins, Baltimore/London, 298-331.
  21. Manna KK, Dastidar SG. (1984) The anti-hypotensive drug propranolol hydrochloride (carditap): its antibacterial property. Proc VI Natl Cong IAMM, 137-141.
  22. Mazumdar K, Ganguly K, Asok Kumar K, Dutta NK, Chakrabarty AN, Dastidar SG. (2003) Antimicrobial potentiality of a new non-antibiotic: the cardiovascular drug oxyfedrine hydrochloride. Microbiol. Res. 158, 259-264. https://doi.org/10.1078/0944-5013-00204
  23. National Committee for Clinical Laboratory Standards. (1993) Methods for Dilution in Antimicrobial Susceptibility Tests; Approved Standard M2-A5. NCCLS, Villanova, PA.
  24. Radhakrishnan V, Ganguly K, Ganguly M, Dastidar SG, Chakrabarty AN. (1999) Potentiality of tricyclic compound thioridazine as an effective antibacterial and antiplasmid agent. Indian J. Exp. Biol. 37, 671-675.
  25. Sarkar A, Kumar KA, Dutta NK, Chakraborty P, Dastidar SG. (2003) Evaluation of in vitro and in vivo antibacterial activity of dobutamine hydrochloride. Indian J. Med. Microbiol. 21, 172-178.