Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Effects of Keumsa Sangwhang (Phellinus linteus) Mushroom Extracts on the Natural Killer Cell Activity in Human

금사상황버섯 추출물이 사람의 natural killer 세포 활성에 미치는 영향

  • Eom, Sang-Yong (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Zhang, Yan-Wei (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Kim, Nam-Sik (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Kang, Jong-Won (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Hahn, Youn-Soo (Department of Pediatrics, College of Medicine, Chungbuk National University) ;
  • Shin, Kyeong-Seob (Department of Laboratory Medicine, College of Medicine, Chungbuk National University) ;
  • Song, Hyung-Gen (Department of Pathology, College of Medicine, Chungbuk National University) ;
  • Park, Soon-Young (Department of Preventive Medicine, College of Medicine, Kyung-Hee University) ;
  • Kim, Jeong-Su (Department of Physiology & Biophysics, College of Medicine, University of Alabama at Birmingham) ;
  • Kim, Heon (Department of Preventive Medicine, College of Medicine, Chungbuk National University) ;
  • Kim, Yong-Dae (Department of Preventive Medicine, College of Medicine, Chungbuk National University)
  • 엄상용 (충북대학교 의과대학 예방의학교실) ;
  • 장연위 (충북대학교 의과대학 예방의학교실) ;
  • 김남식 (충북대학교 의과대학 예방의학교실) ;
  • 강종원 (충북대학교 의과대학 예방의학교실) ;
  • 한윤수 (충북대학교 의과대학 소아과학 교실) ;
  • 신경섭 (충북대학교 의과대학 진단검사의학교실) ;
  • 송형근 (충북대학교 의과대학 병리학교실) ;
  • 박순영 (경희대학교 의과대학 예방의학교실) ;
  • 김정수 (알라바마 의과대학 생리 및 생물물리학과) ;
  • 김헌 (충북대학교 의과대학 예방의학교실) ;
  • 김용대 (충북대학교 의과대학 예방의학교실)
  • Published : 2006.10.01
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Abstract

A randomized, double blind, placebo-controlled human intervention study involving 62 healthy volunteers was performed to investigate the effects of Keumsa sangwhang (Phellinus linteus) mushroom extracts (KPLE) on natural killer (NK) cell activity in peripheral blood. The volunteers were randomly distributed into two groups, one receiving KPLE (3.3 g/day) and the other a placebo by oral administration for 8 weeks. In this study, the number of NK cells did not increase with KPLE administration, however the cytotoxic activity of NK cells against the Jurkat leukemia cell line increased significantly. This result suggests that administration of KPLE induces cell-mediated immunity by increasing NK cell activity in humans.

금사상황버섯의 추출물이 NK 세포 활성에 미치는 영향을 인체 실험을 통해 조사하였다. 대상자는 금사상황버섯 추출물 복용 군과 위약 복용군 각각 31명씩이었으며 총 8주간 상황버섯 추출물 및 위약을 하루 3캡슐씩 2회, 총 6캡슐 (3.3 g/일) 매일 경구 복용하였다. 연구 결과, NK 세포의 지표로 알려진 $CD56^+$ 세포의 수는 금사상황버섯 추출물 복용에 의해 근소한 증가를 나타냈으나 통계적인 유의성은 없었고, 대조군과의 비교에서도 유의한 차이를 나타내지 않았다. 한편, NK 세포의 활성은, 금사상황 버섯 추출물을 복용한 군에서는 Jurkat 세포주에 대한 세포독성이 복용 전에 비해 유의하게 증기한 반면, 대조군의 경우는 차이가 없는 것으로 나타났다. 본 연구의 결과로부터 금사상황버섯 추출물의 복용은 NK 세포의 수적인 증가를 유도하지는 않지만 그 가능의 활성화를 통해 세포성면역을 향상시키는 것으로 생각된다.

Keywords

References

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