Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
권호 표지

Effect of Fermented Guava (Psidium guajava L.) Leaf Extract on Hyperglycemia in Low Dose Streptozotocin-induced Diabetic Mice

저용량 Streptozotocin으로 유도된 당뇨모델 생쥐에서 발효 구아바 잎 추출물의 고혈당 억제 효과

  • Jin, Yeong-Jun (Department of Life Science and Technology Innovation Center for Life Science, Cheju National University) ;
  • Kang, Shin-Hae (Jeju Hi-Tech Industry Development Institute) ;
  • Choi, Soo-Youn (Department of Life Science and Technology Innovation Center for Life Science, Cheju National University) ;
  • Park, Soo-Young (Jeju Hi-Tech Industry Development Institute) ;
  • Park, Ji-Gweon (Department of Life Science and Technology Innovation Center for Life Science, Cheju National University) ;
  • Moon, Sang-Wook (Fermentech Co. Ltd.) ;
  • Park, Deok-Bae (Department of Medicine, Cheju National University) ;
  • Kim, Se-Jae (Department of Life Science and Technology Innovation Center for Life Science, Cheju National University)
  • 진영준 (제주대학교 생명과학과.생명과학기술혁신센터) ;
  • 강신해 (제주하이테크산업진흥원) ;
  • 최수연 (제주대학교 생명과학과.생명과학기술혁신센터) ;
  • 박수영 (제주하이테크산업진흥원) ;
  • 박지권 (제주대학교 생명과학과.생명과학기술혁신센터) ;
  • 문상욱 ((주)퍼멘텍) ;
  • 박덕배 (제주대학교 의학과) ;
  • 김세재 (제주대학교 생명과학과.생명과학기술혁신센터)
  • Published : 2006.10.01
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Abstract

The effects of dried and fermented guava (Psidium guajava L.) leaf extracts on blood glucose levels were investigated in low-dose streptozotocin(STZ)-induced diabetic mice. Fermented guava leaf extract (500 mg/kg/day) significantly decreased the fasting blood glucose levels after 2-4 weeks of treatment and improved the impaired glucose tolerance in STZ-induced diabetic mice. On the other hand, dried guava leaf extract lowered the blood glucose levels and improved glucose tolerance two weeks after treatment, but exacerbated STZ-induced high blood glucose levels three and four weeks after treatment. Histological and immunohistochemical observation showed that fermented guava leaf extract treatment improved STZ-induced pancreatic beta-cell damage, but dried guava leaf extract did not affect the damage to the beta-cells. These results suggest that fermented guava (Psidium guajava L.) leaf extracts improve the hyperglycemia by protecting the pancreatic beta-cells hom damage in STZ-induced diabetic mice.

저 용량 Streptozotocin(STZ)으로 유도한 제l형 당뇨 모델 생쥐에서 건조 구아바 잎과 발효 구아바 잎 에탄올 추출물의 혈당에 미치는 영향을 비교하였다. STZ로 유도된 쥐에서 발효 구아바 잎 추출물(500 mg/kg/day)은 투여 4주후에도 공복 혈당이 유의적으로 감소하였으며 내당능 장애도 개선되었음을 보여 주었다. 한편 건조 구아바 잎 추출물은 투여 후 2주 동안 공복 혈당이 낮게 나타났으며 내당능 장애도 개선되었지만 3주후부터 고혈당으로 약화되었다. 각 실험군에서 적출한 췌장 조직과 인슐린의 면역 조직 화학 분석 결과, 발효 구아바 잎 추출물은 STZ로 유도된 췌장섬 세포의 손상을 억제하는 것이 관찰되었으나 건조 구아바 잎 추출물은 베타 세포의 손상에 영향을 주지 못하였다. 본 연구 결과는 STZ로 유도된 당뇨 모델 생쥐에서 발효 구아바 잎 추출물이 췌장 베타 세포의 손상을 보호함으로서 혈당 개선 효과를 나타냄을 보여준다.

Keywords

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