Korean Journal of Oriental Medicine (한국한의학연구원논문집)
- Volume 12 Issue 1
- /
- Pages.59-68
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- 2006
- /
- 1229-3377(pISSN)
Microarray Profiles of Ligustici Rhizoma on the Pain Model of Mouse Induced by Acetic Acid
고본(藁本)의 초산으로 유발된 생쥐 통증모델에 대한 마이크로어레이 유전자 발현 양상
-
Kim, Myung-Gyou
(College of Pharmacy, Woosuk University)
;
-
Kim, Chang-Ju
(College of Medicine, Kyung Hee University)
;
- Hong, Mee-Suk (College of Medicine, Kyung Hee University) ;
-
Chung, Joo-Ho
(College of Medicine, Kyung Hee University)
;
-
Boo, Yung-Min
(College of Pharmacy, Woosuk University)
;
-
Kim, Yun-Kyung
(College of Pharmacy, Wonkwang University)
;
-
Hong, Seung-Heon
(College of Pharmacy, Wonkwang University)
;
-
Leem, Kang-Hyun
(College of Oriental Medicine, emyung University)
-
김명규
(우석대학교 한약학과)
;
-
김창주
(경희대학교 의과대학)
;
- 홍미숙 (경희대학교 의과대학) ;
-
정주호
(경희대학교 의과대학)
;
-
부영민
(우석대학교 한약학과)
;
-
김윤경
(원광대학교 한약학과)
;
-
홍승헌
(원광대학교 한약학과)
;
-
임강현
(세명대학교 한의과대학)
- Published : 2006.06.30
Abstract
The present study was designed to investigate the effects of Ligustici Rhizoma on the expression of genes in the pain model induced by acetic acid. cDNA microarray (GenePlorer TwinChipTM Mouse 7.4K) was used to evaluate the gene expressions. The expressions of 32 genes were up-regulated in the Ligustici Rhizoma-treated group: they include the genes coding Casp6, Hrh3, Basp1, Sprr2h, Zfp131, Copz2, LOC432436, Itpr5, etc. The expressions of 16 genes were down-regulated in the Ligustici Rhizoma-treated group: they include the genes coding Il16, Zfpm1, Cacna2d1, Xpo7, Smpdl3b, Dscr1, Harp, etc. The conclusion is that the expressions of 32 genes were up-regulated and the expressions of 16 genes were down-regulated in Ligustici Rhizoma-treated group.