Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Constituents from Hypericum ascyron

물레나물 (Hypericum ascyron)의 성분

  • Chae, Sung-Wook (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Lee, So-Young (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kim, Ju-Sun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Kim, Sung-Kyu (Vitaminhouse R&BT) ;
  • Kang, Sam-Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University)
  • 채성욱 (서울대학교 약학대학 천연물과학연구소) ;
  • 이소영 (서울대학교 약학대학 천연물과학연구소) ;
  • 김주선 (서울대학교 약학대학 천연물과학연구소) ;
  • 배기환 (충남대학교 약학대학) ;
  • 김성규 (비타민하우스R&BT) ;
  • 강삼식 (서울대학교 약학대학 천연물과학연구소)
  • Published : 2006.09.30
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Abstract

The isolation and identification of a new xanthone (6-0-palmitolyl-1,6-dihydroxy-5,7-dimethoxyxanthone) along with n-alkanols, fatty acids, 1,6-dihydroxy-5,7-dimethoxyxanthone, 1,7-dihydroxykanthone, betulinic acid, ${\beta}-sitosterol$, methyl 4-hydroxybenzoate, quercetin, and kaempferol from the aerial parts of Hypericum ascyron was reported. The structures were elucidated by spectroscopic methods, mainly NMR and mass spectrometry.

Keywords

References

  1. Ross, I. A. (2001) Medicinal Plants of the World. Vol. 2, Chemical Constituents, Traditional and Modem Medicinal Uses. Humana Press, Totowa, New Jersey
  2. McKenna, D. J., Jones, K. and Hughes, K. (2002) Botanical Medicines. The Desk Reference for Major Herbal Supplements. 2nd Ed., 923-986, The Haworth Herbal Press, New York
  3. Ebadi, M. (2002) Phannacodynamic Basis of Herbal Medicine. 2nd Ed., 457-470, CRC Press, Boca Raton
  4. Jiang Su New Medical College (1977) Dictionary of Chinese Crude Drugs. Shanghai Scientific Technological Publishers, Shanghai
  5. 이창복 (1989) 대한식물도감, 544-546, 향문사, 서울
  6. 배기환 (2000) 한국의 약용식물, 176, 교학사, 서울
  7. Hu, L.-P., Yip, S.-C. and Sim, K.-Y. (1999) Xanthones from Hypericum ascyron. Phytochemistry 52: 1371-1373 https://doi.org/10.1016/S0031-9422(99)00412-4
  8. Wang, Z. Q. and Wang, X. R. (1980) Studies on the Constituents of Hong Han Lian (Hypericum ascyron L.). Acta Pharm. Sin. 15: 365-367
  9. 정칠만, 황은주, 권학철, 김선여, 배기환, 지옥표, 이강노 (1996) 고추나물의 항산화 활성 Flavonoid성분, 생약학회지 30: 196-201
  10. Don, M.-J, Huang, Y.-J, Huang, R.-L. and Lin, Y.-L. (2004) New Phenolic Principles from Hypericum sampsonii. Chem. Pharm. Bull. 52: 866-869 https://doi.org/10.1248/cpb.52.866
  11. Chen, M.-T., Wang, C.-H., Chen, C.-M. and Kuoh, C.-S. (1988) Flavonoids from Hypericum nagasawai Hayata. J. Chin. Chem. Soc. 35: 167-172 https://doi.org/10.1002/jccs.198800024
  12. EI-Seedi, H. R., Ringbom, T., Torssell, K. and Bohlin, L. (2003) Constituents of Hypericum laricifolium and Their Cyclooxygenase (COX) Enzyme Activities. Chem. Pharm. Bull. 51: 1439-1440 https://doi.org/10.1248/cpb.51.1439
  13. Cakir, A., Mavi, A, Yldrm, A., Duru, M. E., Harmandar, M. and Kazaz, C. (2003) Isolation and characterization of antioxidant phenolic compounds from the aerial parts of Hypericum hyssopifolium L. by activity-guided fractionation. J. Ethnopharmacol. 87: 73-83 https://doi.org/10.1016/S0378-8741(03)00112-0
  14. Chen, M.-T., Kuoh, Y.-P., Wang, C.-H., Chen, C.-M. and Kuoh, C.-H. (1989) Additional Constituents of Hypericum subalatum. J. Chin. Chem. Soc. 36: 165-168 https://doi.org/10.1002/jccs.198900025
  15. Cardona, M. L., Fernandez, M. I., Pedro, J. R., Seoane, E. and Vidal, R. (1986) Additional New Xanthones and Xanthonolignoids from Hypericum canariensis. J Nat. Prod. 49: 95-100 https://doi.org/10.1021/np50043a010
  16. Alves de Lima, R., Gottlieb, O. R. and Lins Mesquita, A. A. (1972) Xanthones from Caraipa densiflora. Phytochemistry 11: 2307-2309 https://doi.org/10.1016/S0031-9422(00)88395-8
  17. Tanaka, N., Takaishi, Y., Shikishima, Y., Nakanishi, Y., Bastow, K., Lee, K.-H., Honda, G., Ito, M., Takeda, Y., Kodzhimatov, O. K. and Ashurmetov, O. (2004) Prenylated Benzophenones and Xanthones from Hypericum scabrum. J Nat. Prod. 67: 1870-1875 https://doi.org/10.1021/np040024+
  18. Hong, D., Yin, F., Hu, L.-H. and Lu, P. (2004) Sulfonated xanthones from Hypericum sampsonii. Phytochemistry 65:2595-2598 https://doi.org/10.1016/j.phytochem.2004.08.014
  19. WU, Q.-L., Wang, S.-P., Yang, J.-S. and Xiao, P.-G. (1998) Xanthones from Hypericum japonicum and H. henryi. Phytochemistry 49: 1395-1402 https://doi.org/10.1016/S0031-9422(98)00116-2
  20. Gunatilaka, A. A. L., De Silva, A M. Y. J. and Sotheeswaran, S. (1982) Minor Xanthones of Hypericum mysorense. Phytochemistry 21: 1751-1753 https://doi.org/10.1016/S0031-9422(82)85053-X
  21. Cardona, M. L. and Seoane, E. (1982) Xanthone Constituents of Hypericum ericoides. J. Nat. Prod. 45: 134-136 https://doi.org/10.1021/np50020a004
  22. Kijjoa, A, Jose, M., Gonzalez, T. G, Pinto, M. M. M., Damas, A.M., Mondranondra, I., Silva, A. M. S. and Herz, W. (1998) Xanthones from Cratoxylum maingayi. Phytochemistry 49: 2159-2162 https://doi.org/10.1016/S0031-9422(98)00381-1
  23. Locksley, H. D., Moore, I. and Scheinmann, F. (1966) Extractives from Guttiferae. Part II. The Isolation and Structure of Four Polyhydroxyxanthones in Symphonia globulifera L. J. Chem. Soc. (C) 430-432
  24. Yang, X.-D., Xu, L.-Z. and Yang, S.-L. (2001) Xanthones from the stems of Securidaca inappendiculata. Phytochemistry 58: 1245-1249 https://doi.org/10.1016/S0031-9422(01)00356-9
  25. Lin, C.-N., Chung, M.-I., Lion, S.-J., Lee, T.-H. and Wang, J.-P. (1996) Synthesis and Anti-inflammatory Effects of Xanthone Derivatives. J. Pharm. Pharmacol. 48: 532-538 https://doi.org/10.1111/j.2042-7158.1996.tb05969.x
  26. Gamiotea-Turro, D., Cuesta-Rubio, O., Prieto-Gonzalez, S., De Simone, F., Passi, S. and Rastrelli, L. (2004) Antioxidative Constituents from the Leaves of Hypericum styphelioides. J Nat. Prod. 67: 869-871 https://doi.org/10.1021/np030364f
  27. Zou, Y.-P., Lu, Y.-H. and Wei, D.-Z. (2004) Antioxidative Activity of a Flavonoid-rich Extract of Hypericum perforatum L. in Vitro. J Agric. Food Chem. 52; 5023-5039
  28. Luo, L., Sun, Q., Mao, Y. Y., Lu, Y. H. and Tan, R. X. (2004) Inhibitory effects of flavonoids from Hypericum perforatum on nitric oxide synthase. J. Ethnopharmacol. 93: 221-225 https://doi.org/10.1016/j.jep.2004.03.042
  29. Butterweck, V., Christoffel, V., Nahrstedt, A., Petereit, F., Spengler, B. and Winterhoff, H. (2003) Step by step removal of hyperforin and hypericin: Activity profile of different Hypericum preparations in behavioral models. Life Sci. 73: 627-639 https://doi.org/10.1016/S0024-3205(03)00314-X
  30. Mu, Q., Gibbons, S., Stavri, M., Smith, E., Zhou, F.-S. and Hu, C.-Q. (2006) Antibacterial Effects ofHypericum ascyron and Hypericum japonicum against Multidrug-Resistant Staphylococcus aureus. Pharm. Biol. 44: 157-159 https://doi.org/10.1080/13880200600686079