Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Isolation of a Cerebroside from Panax notoginseng

삼칠근(Panax notoginseng)으로부터 Cerebroside의 분리

  • Cho, Min-Jung (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Lee, So-Young (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Kim, Ju-Sun (Natural Products Research Institute and College of Pharmacy, Seoul National University) ;
  • Lee, Je-Hyun (Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Choi, Hwan-Soo (Korea Institute of Oriental Medicine) ;
  • Lee, Ho-Young (Korea Institute of Oriental Medicine) ;
  • Ha, Hye-Kyung (Korea Institute of Oriental Medicine) ;
  • Kim, Chung-Sook (Korea Institute of Oriental Medicine) ;
  • Kang, Sam-Sik (Natural Products Research Institute and College of Pharmacy, Seoul National University)
  • 조민정 (서울대학교 약학대학 천연물과학연구소) ;
  • 이소영 (서울대학교 약학대학 천연물과학연구소) ;
  • 김주선 (서울대학교 약학대학 천연물과학연구소) ;
  • 이제현 (경희대학교 약학대학 한약학과) ;
  • 최환수 (한국한의학연구원) ;
  • 이호영 (한국한의학연구원) ;
  • 하혜경 (한국한의학연구원) ;
  • 김정숙 (한국한의학연구원) ;
  • 강삼식 (서울대학교 약학대학 천연물과학연구소)
  • Published : 2006.06.30
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Abstract

A mixture of cerebrosid was purified from the roots of Panax notogiseng (Araliaceae) and characterized as 1-O-{\beta}-D-glucopyranosyl-(2S,3S,4R,8E)-2-[(2'R)-2‘-hydroxypalmitoylamino]-8-octadecene-1,3,4-triol (Aralia cerebroside) and its 8Z-isomer (1-O-{\beta}-D-glucopyranosyl-(2S,3S,4R,8E)-2-[(2'R)-2’-hydroxypalmitoylamino]-8-octadecene-1,3,4-triol, a major component of poke-weed cerebroside) by means of spectroscopic methods.

Keywords

References

  1. 배기환 (2003) 건강보감, 245, 교학사, 서울
  2. Wang, C.-Z., McEntee, E., Wicks, S., Wu, J.-A., and Yuan, C.-S. (2006) Phytochemical and Analytical Studies of Panax notoginseng (Burk.) F.H. Chen, J. Nat. Med., 60: 97-105 https://doi.org/10.1007/s11418-005-0027-x
  3. Komakine, N., Okasaka, M., Takaishi, Y., Kawazoe, K., Murakami, K., and Yamada, Y. (2006) New DammaraneType Saponin from Roots of Panax notoginseng, J. Nat. Med., 60: 135-137 https://doi.org/10.1007/s11418-005-0016-0
  4. Kang, S.S., Kim, J.S., Xu, Y.N., and Kim, Y.H. (1999) Isolation of a New Cerebroside from the Root Bark of Aralia elata, J. Nat. Prod., 62: 1059-1060 https://doi.org/10.1021/np990018r
  5. Kang, S.S., Kim, J.S., Son, K.H., Kim, H.P., and Chang, H.W. (2001) Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix, Chem. Pharm. Bull., 49: 321-323 https://doi.org/10.1248/cpb.49.321
  6. Ryu, J.-Y., Kim, J.S., and Kang, S.S. (2003) Cerebrosides from Longan Arillus, Arch. Pharrn. Res., 26: 138-142 https://doi.org/10.1007/BF02976659
  7. Kim, J.S., Byun, J.H., and Kang, S.S. (2001) Isolation of Soya-cerebrosideI from the Roots of Trichosanthes kirilowii, Nat. Prod. Sci., 7: 27-32
  8. Jung, J.H., Lee, C.-O., Kim, Y.C., and Kang, S.S. (1996) New Bioactive Cerebrosides from Arisaema amurense, J. Nat. Prod., 59: 319-322 https://doi.org/10.1021/np960201+
  9. Falsone, G., Cateni, F., Visintin, G., Lucchini, V., Wagner, H., and Seligmann, O. (1994) Constituents of Euphorbiaceae 12. Comm. (1) Isolation and Structure Elucidation of Four New Cerebrosides from Euphorbia biglandulosa Desf, IL FARMACO, 49: 167-174
  10. Falsone, G., Cateni, F., Baumgartner, M., Lucchini, V., Wagner, H., and Seligmann, O. (1994) Constituents of Euphorbiaceae 13.Comm. (1) Isolation and Structure Elucidation of Five Cerebrosides from Euphorbia characias L., Z. Naturforsch., 49B: 135-140
  11. Sugiyama, S., Honda, M., and Komori, T. (1990) Stereochemistry of the Four Diastereomers of Phytosphingosine, Liebigs Ann. Chem., 1069-1078
  12. Sugiyama, S., Honda, M., Higuchi, R., and Komori, T. (1991) Stereochemsitry of the Four Diastereomers of Ceramide and Ceramide Lactoside, Liebigs Ann. Chem., 349-356
  13. Couperus, P.A., Clague, A.D.H. and Van Dongen, J.P.C.M. (1976) $^{13}C$ Chemical Shifts of Some Model Olefins, Org. Magn. Reson., 8: 426-431 https://doi.org/10.1002/mrc.1270080807
  14. Fusetani, N., Yasumuro, K., Matsunaga, S., and Hirota, H. (1989) Haliclamines A and B, Cytotoxic Macrocyclic Alkaloids from a Sponge of the Genus Haliclona, Tetrahedron Lett., 30: 6891-6894 https://doi.org/10.1016/S0040-4039(01)93381-7
  15. Koga, J., Yamauchi, T., Shimura, M., Ogawa, N., Oshima, K., Umemura, K., Kikuchi, M., and Ogasawara N. (1998) Cerebrosides A and C, Sphingolipid Elicitors of Hypersensitive Cell Death and Phytoalexin Accumulation in Rice Plants, J. Biol. Chem., 273: 31985-31991 https://doi.org/10.1074/jbc.273.48.31985
  16. Hori, T. and Sugita, M. (1993) Sphingolipids in Lower Animals, Prog. Lipid Res., 32: 25-45 https://doi.org/10.1016/0163-7827(93)90003-F
  17. Liao, J., Tao, J., Lin, G. and Liu, D. (2005) Chemistry and Biology of Sphingolipids, Tetrahedron, 61: 4715-4733 https://doi.org/10.1016/j.tet.2005.02.075
  18. Muralidhar, P., Radhika, P., Krishna, N., Venkata Rao, D., and Rao, C.B. (2003)Sphingolipids from Marine Organisms: A Review, Nat. Prod. Sci., 9: 117-142