Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Inhibiting Activity of Garlic on a Drug Metabolizing Enzyme CYP3A4

마늘의 약물대사효소 CYP3A4 저해 활성

  • Lee, Eun-Hee (Department of Bio-Industry and Technology, Sangji University) ;
  • Cha, Bae-Cheon (Department of Bio-Industry and Technology, Sangji University)
  • 이은희 (상지대학교 바이오산업공학과) ;
  • 차배천 (상지대학교 바이오산업공학과)
  • Published : 2006.06.30
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Abstract

Garlic(Allium sativum Linn) is widely used as a common condiment for a variety of foods and beverages. It has been well known that fresh garlic and garlic supplement of commercial preparations have various therapeutic properties including antimicrobial activity, antiplatelet aggregation, antihypertension, and cholesterol-lowering effects, which contribute to its increasing uses for an alternative medicine. Allicin(diallyl thiosulfinate), the major bioactive components of garlic, is formed by alliinase cleavage of the naturally occurring alliin upon crushing or mincing of garlic, and is the progenitor of a number of other products, such as diallyl disulfide. CYP3A4, heme-containing monooxygenase, is a key enzyme responsible for drug metabolism. Therefor, in the present study, we isolated and examined the compounds with CYP3A4-inhibiting activities from garlic. Among EtOAc extracts of garlic, we found that N-p-coumaroyltyramine and N-feruloyltyramine showed remarkable CYP3A4-inhibiting activities, compared to diallyl disulfide. Structures of the isolated active compounds were established by chemical and spectroscopic means.

Keywords

References

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