Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Preliminary Study on the Antisnake Venom Activity of Alcoholic Root Extract of Clerodendrum viscosum (Vent.) in Naja naja Venom

  • Lobo, Richard (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences) ;
  • Punitha, I.S.R. (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences) ;
  • Rajendran, K. (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences) ;
  • Shirwaikar, Arun (Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences) ;
  • Shirwaikar, Annie (Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences)
  • Published : 2006.09.01
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Abstract

The antisnake venom activity of Clerodendrum viscosum Vent. (Fam. Verbenaceae), a plant traditionally used in India for the treatment of snake bite was evaluated by in vitro and in vivo methods. While in vitro studies were performed using human blood, in vivo studies were carried out using mice administered three different i.p doses of the extract, 5 min before the administration of Naja naja snake venom. The results of the in vitro studies showed that the extract probably interacts with but does not stabilize membrane protein. In the in vivo studies the extract showed significant antisnake venom activity, which may be attributed to its possible interference with the acetylcholine receptor sites. Hence the present investigation justifies the traditional use of Clerodendrum viscosum (C. viscosum) as antisnake venom.

Keywords

References

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