Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antiallergic Effect of Two Variants of Artemisia princeps Pampanini

  • Shin, Yong-Wook (College of Pharmacy, Kyung Hee University) ;
  • Bae, Eun-Ah (College of Pharmacy, Kyung Hee University) ;
  • Lee, Bo-Mi (College of Pharmacy, Kyung Hee University) ;
  • Min, Sung-Won (College of Pharmacy, Kyung Hee University) ;
  • Lee, Jin-Hee (Graduate School of Biotechnology and PMRC, Kyung Hee University) ;
  • Baek, Nam-In (Graduate School of Biotechnology and PMRC, Kyung Hee University) ;
  • Ryu, Su-No (Department of agricultural Science Korea National Open University) ;
  • Chung, Hae-Gon (Ganghwa Agricultural R&D Center) ;
  • Kim, Nam-Jae (Institute of East and West Medical Research, Kyung Hee University) ;
  • Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
  • Published : 2006.06.01
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Abstract

Antiallergic activities of two variants of Artemisia princeps Pampanini SJ-1 (named as Sajabalssuk) and SS-1 (named as Sajuarissuk) cultivated in Ganghwado, which contain high content of eupatilin compared to those cultured by other places, were investigated to evaluate the possibility as inhibitors against allergic diseases. Ethanol and supercritical fluid extracts of SJ-1 and SS-1 inhibited the release of ${\beta}-hexosaminidase$ from RBL-2H3 cells, although their water extracts were inactive. These extracts potently inhibited lipopolysaccharide-induced NO production of RAW264.7. However, these extracts almost did not scavenge free radicals. Oral administration of these extracts to mice inhibited passive cutaneous anaphylaxis reaction induced by IgE, and acute dermatitis induced by 12-O-tetradecanoylphorbol-13-acetate. However, these extracts did not inhibit chronic dermatitis. Scratching behaviors, vascular permeability, and writhing syndromes were weakly inhibited by these extract at a dose of 50 mg/kg. Based on these findings, we believe that SJ-1 and SS-1 can improve IgE-induced allergic diseases such as rhinitis and asthma.

Keywords

References

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