Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The effects of Banhabaekchulchunma-Tang(BCT) on Dementia induced by focal brain ischemic injury in rats

반하백출천마탕(半夏白朮天麻湯)이 국소(局所) 뇌허혈(腦虛血)로 인(因)한 치매 병태 백서(白鼠)에 미치는 영향(影響)

  • Won, Ho-Young (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongshin univ.) ;
  • Choi, Chang-Won (Dept. of Oriental Internal medicine, College of Oriental Medicine, Dongshin univ.) ;
  • Kim, Kyung-Su (Dep. of Family medicine, Dongshin University Hospital) ;
  • Kim, Kyeong-Ok (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongshin univ.) ;
  • Lee, Dong-Won (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongshin univ.) ;
  • Kim, Su-Youn (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dongshin univ.)
  • 원호영 (동신대학교 한의과대학 한방신경정신과학교실) ;
  • 최창원 (동신대학교 한의과대학 한방내과학교실) ;
  • 김경수 (동신대한방병원 가정의학과교실) ;
  • 김경옥 (동신대학교 한의과대학 한방신경정신과학교실) ;
  • 이동원 (동신대학교 한의과대학 한방신경정신과학교실) ;
  • 김수연 (동신대학교 한의과대학 한방신경정신과학교실)
  • Published : 2006.07.30
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Abstract

Objective : This study was to investigate the effects of Banhabaekchulchunma-Tang(BCT) on Dementia induced by focal ischemic injury in the rats. Method : Experimental groups were divided into 4 groups ; Normal group, Control group, BCT1 group and BCT2 group. Control group were no treated after focal brain ischemic injury. BCT1 group were administered BCT 0.3 ml/kg to focal brain ischemic injuried rats for 21 days, BCT2 group were administered BCT 1.2 ml/kg to focal brain ischemic injuried rats for 21 days. The present author observed the number of errors on the eight-arm radial maze task , the rate of correct choice on the eight-arm radial maze task, the values of density of Cresyl Violet-stained sections in the hippocampal CA1 and the values of density of Acetlycholin Esterase(AchE) stained nuclei in the hippocampal CA1. Result : 1. The number of errors in the eight-arm radial maze task was significantly decreased in BCT1 group on 1-6th days. And it was significantly decreased in BCT2 group on 1st, 2nd, 3rd and 6th day compared with control group. 2. The rate of correct choice on the eight-arm radial maze task was increased in BCT1 group and BCT2 group compared with control group, but the value was not significant. 3. The values of density of Cresyl Violet-stained sections in the hippocampal CA1 were significantly increased in BCT1 group and BCT2 group compared with control group. 4. The values of density of AchE stained nuclei in the hippocampal CA1 were significantly increased in BCT1 group compared with control group. Conclusion : The present author thought that Banhabaekchulchunma-Tang could be used to cure dementia derived by the phlegm retention of fluid.

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