동의신경정신과학회지 (Journal of Oriental Neuropsychiatry)

  • 제17권2호
  • /
  • Pages.37-59
  • /
  • 2006
  • /
  • 1226-6396(pISSN)
  • /
  • 2234-4942(eISSN)
대한한방신경정신과학회 (The Korean Society of Oriental Neuropsychiatry)
권호 표지

황연해독탕(黃連解毒湯)이 Hypoxia-reoxygenation에 의해 손상 받은 Mouse Neuroblastoma 2a Cells에 미치는 영향(影響)

The effects of Hwangryunhaedoktang and herbs on Mouse neuroblastoma 2a cells damaged by hypoxia-reoxygenation

  • 안상훈 (경희대학교 한의과대학 신경정신의학교실) ;
  • 김종우 (경희대학교 한의과대학 신경정신의학교실) ;
  • 강철훈 (경희대학교 동서의학대학원) ;
  • 황의완 (경희대학교 한의과대학 신경정신의학교실)
  • Ahn, Sang-Hoon (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Jong-Woo (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyung-Hee University) ;
  • Kang, Chul-Hun (Graduate School of East-West Medical Science) ;
  • Whang, Wei-Wan (Dept. of Neuropsychiatry, College of Oriental Medicine, Kyung-Hee University)
  • 발행 : 2006.07.30
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초록

Objective : This study was designed to asses the effect of Hwangryunhaedoktang and herbs on Mouse neuroblastoma 2a cells damaged by hypoxia-reoxygenation. Method : Mouse neuroblastoma 2a (N2a) cells were measured by MTT assay and LDH assay after 48h hypoxia and 6h reoxygenation. Mouse neuroblastoma 2a (N2a) cells were treated by Hwangryunhaedoktang and herbs. Result : 1. Hwangryunhaedoktang was effective on LDH assay of hypoxia and reoxygenation. 2. All of herbs were generally effective on LDH assay of hypoxia and reoxygenation. In LDH assay of hypoxia, the effects of herbs depended on concentration. In MTT assay of hypoxia, Coptidis Rhizoma and Gardeniae Fructus were effective. In MTT assay of reoxygenation most of herbs were not effective. But Phellodendri Cortex was effective in high concentration. Conclusion : The results imply that Hwangryunhaedoktang and all herbs of it nay have protective effect on dementia and aging.

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