대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)
- 제20권1호
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- Pages.165-180
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- 2006
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- 1226-8038(pISSN)
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- 2287-9463(eISSN)
수종의 한약재가 Streptozotocin으로 유발된 고혈당 생쥐에 미치는 영향
The Effects of Several Herbal Medicine Concentrated Solution on the Hyperglycemic Mice Induced with Streptozotocin
- Chae, Jung-Won (Department of Pediatrics, College of Oriental Medicine, Dongshin University) ;
- Ju, Suk-Hyun (Department of Pediatrics, College of Oriental Medicine, Dongshin University)
- 발행 : 2006.04.30
초록
Objective : This study has been carried out to understand the effect of several herbal medicine concentrated solution on the hyperglycemic mice Induced with streptozotocin(STZ). Methods : The 60 mg/kg of STZ injection into mice twice by 24 h interval and then 120 mg/kg of STZ injection again 3 days after the earlier injection. Control group was subjected to natural recovery, however, treated groups were fed 0.2 ml of several herbal medicine-concentrated solution (PA (x2, several herbal medicine-concentrated solution 1 group); PB (x4 several herbal medicine-concentrated solution 2 group) daily for 6 weeks. Result : The weight of PA was higher than that of control, but weight of PB was lower than control. The blood level of control increased continuously, reaching to 350mg/dL after 6 weeks, however, PA and PB showed a fast reduction of blood glucose. In blood glucose tolerance test, PA and PB showed better resistance than control. The GOT level in significantly(p<0.05) decreased in PA and PB compared with control group. The BUN and creatinine levels are significantly(p<0.01) decreased in PA compared with control group. Feeding of several herbal medicine-concentrated solution in a concentration of PA had an efficient effect on regeneration or recovery of Langerhans islet and
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