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The Pharmaceutical Society of Korea (대한약학회)
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A New Monoterpene Glycoside and Antibacterial Monoterpene Glycosides from Paeonia suffruticosa

  • An, Ren-Bo (College of Pharmacy, Wonkwang University,College of Pharmacy, Yanbian University) ;
  • Kim, Hyun-Chul (College of Pharmacy, Wonkwang University) ;
  • Lee, Sung-Hee (College of Pharmacy, Wonkwang University) ;
  • Jeong, Gil-Saeng (College of Pharmacy, Wonkwang University) ;
  • Sohn, Dong-Hwan (College of Pharmacy, Wonkwang University) ;
  • Park, Hyun (Department of Infection Biology, College of Medicine, Wonkwang University) ;
  • Kwon, Dong-Yeul (College of Pharmacy, Wonkwang University) ;
  • Lee, John-Hwa (College of Veterinary Medicine and Bio-Safety Research Institute, Chonbuk National University) ;
  • Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
  • Published : 2006.10.01
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Abstract

Antibacterial activity-guided fractionation of the $CHCl_3-MeOH$ (1:1) extract of Paeonia suffruticosa root bark furnished three monoterpene glycosides, 6-O-vanillyoxypaeoniflorin (1), mudanpioside-H (2), and galloyl-oxypaeoniflorin (3). Of the isolated compounds, compound 1 is a new compound. All isolated compounds showed broad, but moderate, antibacterial activity with minimum inhibitory concentration (MIC) values in the range of 100 to $500\;{\mu}g/mL$ against eighteen pathogenic microorganisms of concern for public health or zoonosis.

Keywords

References

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