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The Pharmaceutical Society of Korea (대한약학회)
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Four Butenolides are Novel Cytotoxic Compounds Isolated from the Marine-Derived Bacterium, Streptoverticillium luteoverticillatum 11014

  • Li, De-Hai (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China) ;
  • Zhu, Tian-Jiao (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China) ;
  • Liu, Hong-Bing (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China) ;
  • Fang, Yu-Chun (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China) ;
  • Gu, Qian-Qun (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China) ;
  • Zhu, Wei-Ming (Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China)
  • Published : 2006.08.01
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Abstract

Four known butenolides were isolated from the ethyl acetate extracts of the culture broth of the marine-derived bacterium, Streptoverticillium luteoverticillatum, by bioassay-guided fractionation. The structures were identified on the basis of spectral data. The absolute configuration of compound (1) was determined by CD spectrum for the first time. Compounds 1-4 showed in vitro cytotoxicity against the murine lymphoma P388 and human leukemia K562 cell lines. This is the first report on the isolation of butenolides from the marine bacterium, Streptoverticillium luteoverticillatum, and their cytotoxic activities.

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References

  1. Blunt, J. W., Copp, R. C., Munro, M. H. G., Northcote, P. T., and Prinsep, M. R., Marine natural products. Nat. Prod. Rep., 22, 15-64 (2005) https://doi.org/10.1039/b415080p
  2. Braun, D., Pauli, N., Sequin, U., and Zahner, H., New butenolides from the photoconductivity screening of Streptomyces antibioticus (Waksman and Woodruff) Waksman and Henrici 1948. FEMS Microbiol. Lett., 126, 37- 42 (1995) https://doi.org/10.1111/j.1574-6968.1995.tb07387.x
  3. Cho, K. W., Lee, H. S., Rho,J. R., Kim, T. S., Mo, S. J., and Shin, J., New lactone-containing metabolites from a marinederived bacterium of the genus Streptomyces. J. Nat. Prod., 64, 664-667 (2001) https://doi.org/10.1021/np000599g
  4. Mukku, V. J. R. V., Speitling, M., Laatsch, H., and Helmke, E., New butenolides from two marine streptomycetes, J. Nat. Prod., 63, 1570-1572 (2000) https://doi.org/10.1021/np0001676
  5. Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer drug screening. J. Natl Cancer Inst., 82, 1107-1112 (1990) https://doi.org/10.1093/jnci/82.13.1107
  6. Tayyab A. Mansoor, Jongki Hong, Chong-O. Lee, Chung Ja Sim, Kwang Sik Im, Dong Seok Lee, and Jee H. Jung, New cytotoxic metabolites from a marine sponge Homaxinella sp. J. Nat. Prod., 67, 721-724 (2004) https://doi.org/10.1021/np030358j