Archives of Pharmacal Research

  • 제29권7호
  • /
  • Pages.556-562
  • /
  • 2006
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Structure-Activity Relationship Study of Asiatic Acid Derivatives for New Wound Healing Agent

  • 발행 : 2006.07.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Ten semi-synthetic derivatives of asiatic acid were prepared and their wound healing effects were evaluated by employing a tensile strength assay and a wound area assay. Among them, ethoxymethyl 2-oxo-3,23-isopropylidene-asiatate (12) showed the strongest and the fastest wound healing activity. Furthermore, it left the smallest scar after healing.

키워드

참고문헌

  1. Beljanski, M. and Vapaille, N., Role of triterpenes in the binding of L-amino acids by template RNA. Rev. Eur. Etud. Clin. Biol., 16, 897-905 (1971)
  2. Bonte, F., Dumas, M., Chaudagne, C., and Meybeck, A., Asiaticoside and madecassoside comparative activities on human fibroblast type I and III collagen secretion. Ann. Pharm. Fr., 53, 38-42 (1995)
  3. Bontems, J. E., A new heteroside, asiaticoside, isolated from Hydrocotyle asiatica L. (Umbelliferae) Bull. Sci. Pharmacol., 49, 186-191 (1941)
  4. Hunt, T. K., Ehrlich, H. P., Garcia, J. A., and Dunphy, J. E., Effect of vitamin A on reversing the inhibitory effect of cortisone on healing of open wounds in animals and man. Ann. Surg., 170, 633-641 (1969) https://doi.org/10.1097/00000658-196910000-00014
  5. Inamdar, P. K., Yeole, R. D., Ghogare, A. B., and de Souza, N. J., Determination of biologically active constituents in Centella asiatica. J. Chromatography, 742, 127-130 (1996) https://doi.org/10.1016/0021-9673(96)00237-3
  6. Jew, S. S., Yoo, J. H., Lim, D. Y., Kim, H., Mook-Jung, I., Jung, M., Choi, H., Jung, Y.-h., Kim, H., and Park, H.-G., Structureactivity relationship study of Asiatic acide derivatives against ${\beta}$‚ amyloid (A${\beta}$)-induced neurotoxicity. Bioorg. & Med. Chem. Lett., 10, 119-121 (2000) https://doi.org/10.1016/S0960-894X(99)00658-7
  7. Lawrence, J. C., The effect of asiaticoside on guinea pig skin. J. Invest. Dermatol., 49, 95-96 (1967a) https://doi.org/10.1038/jid.1967.11
  8. Lawrence, J. C., The morphological and pharmacological effects of asiaticoside upon skin in vitro and in vivo. Eur. J. Pharmacol., 414-424 (1967b)
  9. Pointel, J. P., Boccalon, H., Cloarec, M., and Ledevehat, J. M., Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology, 38, 46- 50 (1987) https://doi.org/10.1177/000331978703800106
  10. Poizot, A., Dumez, D. C. R., Modification of the kinetics of healing after iterative exeresis in the rat. Action of a triterpenoid and its derivatives on the duration of healing. Acad. Sci. [D], 286, 789-792 (1978)
  11. Schulte, R. and Domenjoz, R., Methode zur Bestimmuny der Reifestigkeit heilender Hautwunden bei Ratten. Med. Pharmacol. Exp., 16, 453 (1967)
  12. Shim, P.-J., Park, J.-H., Chang, M.-S., Lim, M.-J., Kim, D.-H., Jung, Y.-H., Jew, S.-s., Park, E.-H., and Kim, H.-D., Asiaticoside mimetics as wound healing agent. Bioorg. Med. Chem. Lett., 6, 2937-2940 (1996) https://doi.org/10.1016/S0960-894X(96)00540-9
  13. Tavakkol, A., Klingman, L., Morrison, B. M., Jr., and Polefka, T. G., The effects of prolonged use of surfactants on the skin of normal and photo-exposed hairless mice. Contact Dermatitis, 39, 231-239 (1998) https://doi.org/10.1111/j.1600-0536.1998.tb05915.x