대한한방내과학회지 (The Journal of Internal Korean Medicine)
- 제27권2호
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- Pages.471-479
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- 2006
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- 1226-9174(pISSN)
흰쥐의 위(胃) 배출능(排出能)에 대한 반하사심탕(半夏瀉心湯)의 효능(效能)
Effect of Banhasasimtang Granule on Gastric Emptying in Rats
- 이준석 (경희대학교 한의과대학 비계내과학교실) ;
- 김진성 (경희대학교 한의과대학 비계내과학교실) ;
- 류봉하 (경희대학교 한의과대학 비계내과학교실) ;
- 윤상협 (경희대학교 한의과대학 비계내과학교실)
- Lee, Joon-Suk (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Kim, Jin-Sung (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Ryu, Bong-Ha (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
- Yoon, Sang-Hyub (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
- 발행 : 2006.06.30
초록
Backgrounds & Objectives: Banhasasimtang granule(BHSST) has been used for the treatment of functional dyspepsia regarded as one of the gastric dysmotility disease. but its mechanisms of action are not well known yet: So we investigated the effects of BHSST on gastric emptying and its mechanisms of action in rats. Methods: Gastric emptying was measured by glass beads(1mm in diameter) expelled from the stomach for 60 min after administration of normal saline(NS) or BHSST 31mg/kg or 93mg/kg in rats. And by the same method gastric emptying was measured after administration of NS or BHSST 93mg/kg in rats treated with atropine sulfate(1mg/kg, s.c.), quinpirol HCI(0.3mg/kg, i.p.), NAME(NG-nitro-L-arginine methyl ester, 75mg/kg, s.c.) or cisplatin(10mg/kg, i.p.) to make delayed gastric emptying. Results: BHSST 93mg/kg improved gastric emptying more than NS or BHSST 31mg/kg(p=0.016). Under the delayed gastric emptying, BHSST 93mg/kg improved gastric emptying in the group treated with NAME