The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 27 Issue 1
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- Pages.276-287
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- 2006
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- 1226-9174(pISSN)
Effect of Sojukgunbihwan granule on Gastric Motility in Rats
소적건비환과립(消積健脾丸顆粒)이 흰쥐의 위운동성(胃運動性)에 미치는 영향
- Hong, Jong-Hee (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Kim, Jin-Sung (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Ryu, Bong-Ha (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Yoon, Sang-Hyub (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
- 홍종희 (경희대학교 한의과대학 비계내과 교실) ;
- 김진성 (경희대학교 한의과대학 비계내과 교실) ;
- 류봉하 (경희대학교 한의과대학 비계내과 교실) ;
- 윤상협 (경희대학교 한의과대학 비계내과 교실)
- Published : 2006.03.30
Abstract
Background & Objective : The herbal medicine Sojukgunbihwan granule has been used for the treatment of functional dyspepsia, generally categorized as a gastric dysmotility disease. However, its mechanisms are not yet well known. Therefore, the effects of Sojukgunbihwan granules on gastric motility in rats was investigated. Methods : The myoelectrical activity of the gastric smooth muscle was recorded by a bipolar electrode placed at the gastric antrum of rats. The contractile waves were measured for 30 minutes before and after intragastric administration of each solution(normal saline, Pyungwisan 40mg/kg, Sojukgunbihwan granules 60mg/kg) and expressed as the motility index. Gastric emptying was measured by the number of glass beads expelled from the stomach(containing one hundred 1mm glass beads) within an hour after glass beads and test drugs(normal saline, Pyungwisan 40mg/kg, Pyungwisan 120mg/kg, Sojukgunbihwan granules 60mg/kg, Sojukgunbihwan granules 180mg/kg) were administered. In another series of experiments to evaluate the mechanisms of Sojukgunbihwan granules under delayed conditions, the rats were treated with atropine sulfate(1 mg/kg, s.c.), cisplatin(10mg/kg, i.p.), and NAME(