대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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황금이 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향

Effect of Scutellaria Radix extract drug on immune cells and cytokines in BALF of OVA-induced asthmatic mice

  • 조철준 (대전대학교 한의과대학 폐계내과학교실) ;
  • 임도희 (대전대학교 한의과대학 폐계내과학교실) ;
  • 황지호 (대전대학교 한의과대학 폐계내과학교실) ;
  • 양수영 (대전대학교 한의과대학 폐계내과학교실) ;
  • 박양춘 (대전대학교 한의과대학 폐계내과학교실)
  • Cho, Cheol-Jun (Division of Respiratory System, Dep. of Internal Medicine College of Oriental Medicine, Daejeon University) ;
  • Lim, Do-Hee (Division of Respiratory System, Dep. of Internal Medicine College of Oriental Medicine, Daejeon University) ;
  • Hwang, Ji-Ho (Division of Respiratory System, Dep. of Internal Medicine College of Oriental Medicine, Daejeon University) ;
  • Yang, Soo-Young (Division of Respiratory System, Dep. of Internal Medicine College of Oriental Medicine, Daejeon University) ;
  • Park, Yang-Chun (Division of Respiratory System, Dep. of Internal Medicine College of Oriental Medicine, Daejeon University)
  • 발행 : 2006.03.30
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초록

objective : The purpose of this research is to examine the effects of Scutellaria Radix(SR) extract on immune cells and cytokines in ovalbumin(OVA)-induced asthmatic mice. Methods : In vivo, C57BL/6 mice were sensitized and handicapped by OVA for 9 weeks. In this experiment, one group was not treated, and the other group was treated with SR extract for six weeks(five times per week) and analyzed by ELISA and flow cytometer. Results : In vivo, there were significant decreases in eosinophils, IL-4, IL-13 in BALF (bronchoalveolar lavage fluid) compared with that of control group. However,$IFN{\gamma}$ in the SR group increased significantly compared with that of control group. Additionally, the population of $CD3e^-/CCR3^+,\;CD69^+/CD3e^+,\;IgE^+/B220^+,\;CD11b^+/Gr-1^+$ cells in the SR group decreased compared with that of control group. conclusion : The results of this study support a role for SR as an effective treatment for asthma in its experimental success in significantly decreasing inflammation and asthma reactions, and in increasing $IFN{\gamma}$, Which helps prevent such reactions.

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