The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

Anti-inflammatory effect of extract of Asarum sieboldii in LPS-stimulated Murine peritoneal macrophage

LPS로 활성화된 복강 대식세포에서 세신 추출물의 항염증 효과

  • Jung, Won-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Yoo, Hyeon-Mi (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Seo, Sang-Wan (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Cho, Joon-Ki (Dept. of Internal Medicine, IKsan Oriental Hospital) ;
  • Son, Ji-Woo (Dept. of Internal Medicine, IKsan Oriental Hospital) ;
  • Park, Min-Cheol (Dept. of Internal Medicine, IKsan Oriental Hospital) ;
  • Choi, Chang-Min (Dept. of Internal Medicine, Kwangju Oriental Hospital) ;
  • Yeom, Seung-Ryong (Dept. of Internal Medicine, Kwangju Oriental Hospital) ;
  • Hwang, Sang-Wook (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Yong-Woo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Dal-Soo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Chae, Young-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Yeong-Mok (Dept. of Oriental Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Min-Kyo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
  • 정원석 (원광대학교 한의과대학 본초학 교실) ;
  • 유현미 (원광대학교 한의과대학 본초학 교실) ;
  • 서상완 (원광대학교 한의과대학 본초학 교실) ;
  • 조준기 (원광대학교 익산 한방병원) ;
  • 손지우 (원광대학교 익산 한방병원) ;
  • 박민철 (원광대학교 익산 한방병원) ;
  • 최창민 (원광대학교 광주 한방병원) ;
  • 염승룡 (원광대학교 광주 한방병원) ;
  • 황상욱 (원광대학교 한의과대학 본초학 교실) ;
  • 김영우 (원광대학교 한의과대학 본초학 교실) ;
  • 송달수 (원광대학교 한의과대학 본초학 교실) ;
  • 채영석 (원광대학교 한의과대학 본초학 교실) ;
  • 김영목 (원광대학교 한의과대학 병리학 교실) ;
  • 박성주 (원광대학교 한의과대학 본초학 교실) ;
  • 신민교 (원광대학교 한의과대학 본초학 교실) ;
  • 송호준 (원광대학교 한의과대학 본초학 교실)
  • Published : 2006.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : The purpose of this study was to investigate the anti-inflammatory effects of extract Asarum sieboldii(AS) on the peritoneal macrophage. Methods : To evaluate of anti-inflammatory of AS, we examined cytokines production in lipopolysacchride (LPS)-induced macrophages. Furthermore, we checked molecular mechanism using western blot. Results : 1. Extract from AS reduced LPS-induced Nitric oxide (NO), tumor necrosis factor-a (TNF-a), interleukin (IL)-6 and IL-12 production in peritoneal macrophages 2. Extract from AS itself does not have any cytotoxic effect. AS inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase B a (IkBa) in the LPS-stimulated peritoneal macrophages Conclusion : AS down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties of AS

Keywords