The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of APF and CsA on the number of regulatory T cells, NK T cells and gammadelta T cells in OVA-induced murine model of asthma

OVA로 유도된 천식 모델 생쥐에서 목천료자(木天蓼子)가 조절 T 세포, NK T 세포 및 gammadelta T 세포수 변화에 미치는 영향

  • Kim, Seung-Hyung (Institute of Traditional Medicine & Bioscience, Daejeon University) ;
  • Roh, Seong-Soo (Department of Herbology, College of Oriental Medicine, Daejeon University) ;
  • Lee, Jang-Cheon (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Seo, Young-Bae (Department of Herbology, College of Oriental Medicine, Daejeon University) ;
  • Lee, Young-Cheol (Department of Herbology, College of Oriental Medicine, Sangji University)
  • 김승형 (대전대학교 동서생명과학연구원) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 이장천 (상지대학교 한의과대학 본초학교실) ;
  • 서영배 (대전대학교 한의과대학 본초학교실) ;
  • 이영철 (상지대학교 한의과대학 본초학교실)
  • Published : 2006.03.30
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Abstract

Objectives : To clarify the effects of Actinidia polygama and CsA on OVA-induced asthma model, we examined the influence of Actinidia polygama fructus extract (APF) and CsA on the number of regulatory T cells, NKT cells and ${\gamma}{\delta}$ T cells in murine model of asthma. Methods : All mice were immunized on two different days (21 days and 7 days before inhalational exposure) by i.p. injections of OVA in PBS. Seven days after the second sensitization, mice were exposed to aerosolized ovalbumin for 30 min/day on 3 days/week for 12 weeks and APF (400, 40 mg/kg) were orally administered 3 times a week for 8 weeks. Results : The suppressive effects of APF on asthma model were demonstrated by the increase the number of regulatory T cells, ${\gamma}{\delta}$ T cells and by reducing the number of NK T cells. Conclusion : These results indicate that APF has a deep inhibitory effect on airway inflammation and hyperresponsiveness in murine model of asthma by increase the number of regulatory T cells, and ${\gamma}{\delta}$ T cells and by reducing the number of NK T cells.

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